The overall objective of this study is to evaluate the effects, feasibility, and safety of a comprehensive online Ayurveda whole-systems (WS) intervention that targets the underlying etiological factors influencing mental and physical health symptoms. The primary hypothesis is that home-based adults who participate in the Ayurveda Program for Detox and Lifestyle will experience a decrease in anxiety and depression symptoms over 4 months.

Two Ayurveda-trained medical doctors will lead the Online Ayurveda Program for Detox and Lifestyle, which comprises eight interactive live webinars over ten days. Each 1.5-hour session includes online group meetings focused on addressing the etiological factors contributing to mental and physical ill-health. The program is easily replicable and includes personalized herbal remedies, detoxification procedures, dietary guidelines, yoga exercises, and daily routine practices, all based on traditional Ayurvedic medicine principles. After the ten-day detoxification, participants will continue to follow the diet and lifestyle recommendations and the herbal program for mental and physical health for up to four months. Outcome measures will be assessed at baseline and once a month for four months.

Inclusion Criteria:

• Scored ≥ 5 on the GAD-7
• Scored ≥ 5 on the PHQ-9
• Scored ≥ 5 on the PHQ-15
• Age 18-80 years
• No other psychiatric disorders
• Not receiving specialized treatments for anxiety or depression, nor participating in another clinical trial
• Stable psychiatric medication regimen for more than two months
• No acute or severe medical conditions
• Individuals who are not pregnant or breastfeeding
• Provided informed consent

Exclusion Criteria:

• Scored < 5 on the GAD-7
• Scored < 5 on the PHQ-9
• Scored < 5 on the PHQ-15
• Age under 18 or over 80 years
• Other psychiatric disorders (e.g., suicidal risk)
• Currently undergoing specialized treatments for anxiety and depression, or participating in another clinical trial
• Psychiatric medication regimen for less than 2 months
• Acute or severe medical condition (e.g., stroke, surgery)
• Individuals who are pregnant or breastfeeding
• Inability to provide informed consent

The research data supporting this study's findings are not publicly accessible due to privacy and ethical constraints related to patient consent. However, anonymized data may be available from the authors upon request with permission from the institutional review board of Maharishi International University, Fairfield, Iowa.

IPD will be available six months after the study results are published in a peer-reviewed journal and will be accessible for up to three years after that.

Researchers must submit a methodologically sound proposal for review by the data-sharing committee and the institutional review board of Maharishi International University, Fairfield, Iowa. The committee will approve access, and a data use agreement must be signed prior to data release.