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ClinicalTrials.gov ID

NCT06541652

Lead Sponsor

Federation Francophone de Cancerologie DigestiveOTHER

Overall Status

Recruiting

Study Type

Observational

Enrollment

150Estimated

Last Update Posted

Aug 5, 2025Actual

Start Date

Mar 26, 2024Actual

Primary Completion Date

Feb 2026Estimated

Completion Date

Feb 2031Estimated

Official Title

A French Multicenter Observational Retrospective Study of Rare Primary Liver Cancers

Brief Summary

The aim of this French multicenter retrospective study is to describ rare primary hepatic cancers clinical, histological and radiological features, to obtain a biological tumor and blood collection, and to evaluate the efficacy of treatments received in clinical practice in order to determine optimal therapeutic sequences. This retrospective cohort will be the backbone of future translational studies aimed at identifying new molecular, histological, circulating and radiological tumor biomarkers, potentially useful at every stage of diagnosis and prognostic or theranostic evaluation.

Detailed Description

The aim is to describ rare primary hepatic cancers clinical, histological and radiological features, to obtain a biological tumor and blood collection, and to evaluate the efficacy of treatments received in clinical practice in order to determine optimal therapeutic sequences.

• Hepatocholangiocarcinoma
• Fibrolamellar Carcinoma
• Hepatic Epithelioid Hemangioendothelioma
• Hepatoblastoma
• Hepatic Neuroendocrine Carcinoma
• Hepatic Carcinosarcomas
• Hepatic Cystadenoma
• Hepatic Leiomyosarcomas
• Hepatic Angiosarcomas
• Cholangiocarcinoma

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• 18 years of age or older,
• with histologically proven hepato-cholangiocarcinoma, fibrolamellar hepatocellular carcinoma, epithelioid hemangioendothelioma or hepatic angiosarcoma
• diagnosed after January 01, 2018 living or deceased at the time of registration in the cohort
• for living patients who have not objected to the research: (note of non-objection to be attached° agreeing to participate in ancillary studies must sign the biological consent form for participation in biological studies.

Exclusion Criteria:

• without social security
• No access to tumor block

Observational Model

Cohort

Time Perspective

Other

Lead Sponsor

Federation Francophone de Cancerologie DigestiveOTHER

Collaborators

Société Nationale Française de GastroentérologieOTHER

marianne.latournerie@chu-dijon.fr03 80 29 37 50

peron.jm@chu-toulouse.fr05 61 77 94 83