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The goal of this clinical trial is to learn if platelet rich plasma works to treat early stage trigger finger in adults. It will also learn about the safety platelet rich plasma. The main questions it aims to answer are:
Does platelet rich plasma lower the pain associated with trigger finger of participants? Does it improve the hand grip strength and Q DASH score of participants? Researchers will compare platelet rich plasma to Depo-Medrol steroid (a known standard of care for early stage trigger finger) to see if platelet rich plasma works to treat early trigger finger.
Participants will:
Take platelet rich plasma or a depo-medrol steroid intralesional injection at recruitment into the intervention Visit the clinic once every 4 weeks for checkups and parameter measurements. Investigator will will keep a record of participants progress in symptom remission
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Patients here will have one milliliter of freshly prepared autologus platelet rich plasma injection for the treatment of their trigger finger. |
|
| Group B | Active Comparator | Patients here will have one milliliter(20mg) injection of pfizer Depo-medrol(methylprednisolone acetate) injection for the treatment of their trigger finger. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Platelet rich plasma | Biological | Freshly prepared autologus platelet rich plasma |
| |
| Measure | Description | Time Frame |
|---|---|---|
| symptom resolution post injection | reduction of pain using VAS and absence snapping of finger | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Hand grip strength | measured grip using hand dynamomter | 3 month |
| Q- DASH score | 11-item self reported disability questionnaire that consider upper extremity as one functional unit |
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Inclusion Criteria:
No previous treatment for the affected finger.
Exclusion Criteria:
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Sep 6, 2025 | |
| Reset | Sep 24, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Sep 6, 2025 | Sep 24, 2025 |
| ID | Term |
|---|---|
| D052582 | Trigger Finger Disorder |
| ID | Term |
|---|---|
| D053682 | Tendon Entrapment |
| D052256 | Tendinopathy |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
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All participants will have the same assessment and have blood drawn for CBC. Opaque tape masking of the syringes will be done so that care giver and patients are not aware of interventional drug given.
| Pfizer Depo-medrol |
| Drug |
Methylprednisolone acetate 20mg/ml injection |
|
| 3month |