Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger

A Prospective Randomized Placebo-controlled Trial Comparing Platelet-rich Plasma and Corticosteroid Injection for Treatment of Trigger Finger

Study purpose is to evaluate the effectiveness of Platelet-rich Plasma (PRP) injection in the treatment of trigger finger. We compare PRP to a corticosteroid (methylprednisolone) injection in a prospective randomized triple-blind placebo-controlled study.

Patients with clinically confirmed trigger finger are randomized (1:1:1 computer generated sequence with random block size) to three parallel groups and will receive an injection of either PRP, corticosteroid or placebo (0.9% saline) around the affected tendon sheath in a double-blind setting.

Baseline data is collected and is followed by a phone call at 1 month, and follow-up visits at 3, 6, 12 and 24 months after the intervention. Unveiling of the allocation is at 6 months post-intervention.

The primary outcome measures are:

• Symptom resolution
• Patient-Rated Wrist Evaluation

Secondary outcomes:

• Quick-Disabilities of the Arm, Shoulder and Hand
• Pain Visual Analogue Score
• Global improvement (7-step Likert-scale)
• Grip strength
• Finger range of motion

Inclusion Criteria:

• Age 18 - 75
• Symptom duration > 3 months

Exclusion Criteria:

• Diabetes
• Rheumatoid arthritis or other condition requiring continuous oral corticosteroids
• Previous history of surgery or injection to the affected ray
• Alcohol or drug abuse
• Mental instability