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| Name | Class |
|---|---|
| Beijing Chao Yang Hospital | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| Peking University Shenzhen Hospital | OTHER |
| The First Affiliated Hospital of Shanxi Medical University |
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The main purpose of this study is to validate the effect of an individualized exercise prescription developed based on cardiopulmonary exercise testing (CPET) in subjects with metabolic syndrome. This study aims to assess the improvement in cardiovascular metabolic risk associated with the personalized exercise regimen,known as individualized HIIT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Individualized HIIT Group | Experimental | Participants in this group will receive a type of exercise prescription of High-Intensity Interval Training (HIIT). They will undergo supervised individualized intermittent high-intensity training (HIIT) guided by CPET three times per week under the supervision of the hospital. Participants will also receive guidance on healthy dietary habits. At the end of the 12th week, CPET and inspiratory muscle strength tests will be conducted to evaluate the training effects and adjust the exercise prescription. The total duration of the training will be 24 weeks |
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| Control Group | No Intervention | Participants in this group will receive guidance on healthy dietary habits and exercise methods. They will be informed that after 24 weeks of selection, they will have the option to choose HIIT exercise program or home training. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HIIT | Behavioral | Three times a week, 10 sets each session, for 24 weeks of high-intensity interval training. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in composite cardiovascular disease risk score (z-score) | The primary outcome is the change from baseline in the composite cardiovascular disease risk score (z-score) calculated using resting blood pressure, high-density lipoprotein cholesterol, fasting glucose, waist circumference and triglyceride. Each risk factor will be individually standardized and expressed as sex-specific z-score by using the formula = (value - mean)/standard deviation for each participant. | through study completion, an average of 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical and metabolic indicators | Biochemical indicators including GLU(mmol/L),CHO(mmol/L),TG(mmol/L),LDL-C(mmol/L),HDL-C(mmol/L) etc. | through study completion, an average of 2 year |
| CPET (Cardiopulmonary Exercise Testing) related indicators |
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Inclusion Criteria:
Age between 30 and 65, for both males and females;
Inadequate exercise: Sedentary lifestyle: Sitting for more than 6 hours daily over the past 6 months; Insufficient physical activity evaluated by the International Physical Activity Questionnaire (IPAQ), with an average weekly duration of moderate-intensity physical activity less than 150 minutes or high-intensity physical activity less than 75 minutes;
Meeting the criteria for metabolic syndrome according to the 2009 AHA/IDF definition: Must have three or more of the following: Abdominal obesity(Waist circumference ≥90 cm for males, ≥80 cm for females); Elevated fasting blood glucose: ≥5.6 mmol/L; Elevated blood pressure: Systolic blood pressure ≥130 mm Hg, or diastolic blood pressure ≥85 mm Hg; Elevated fasting triglycerides (TG): ≥1.7 mmol/L (150 mg/dl); Reduced fasting high-density lipoprotein cholesterol (HDL-C): <1.0 mmol/L for males, <1.3 mmol/L for females.
Additionally, must meet the following conditions: TG <500 mg/dl (5.6 mmol/L); fasting blood glucose <7 mmol/L; baseline blood pressure <140/90 mm Hg;
Willingness to improve health status through reasonable exercise.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jun Gao, PhD | Contact | +86-10-82266697 | puthxnk@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi-Da Tang, MD, PhD | Peking University Third Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Recruiting | Beijing | Beijing Municipality | 100191 | China |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| OTHER |
| Qingdao Municipal Hospital | OTHER |
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Peak oxygen uptake（ml/min）
| through study completion, an average of 2 year |
| calf circumference, waist circumference, and hip circumference | Indicators in terms of length include: calf circumference, waist circumference, and hip circumference | through study completion, an average of 2 year |
| Oral Glucose Tolerance Test (OGTT) Related Indicators | Fasting Blood Glucose and Insulin, 30-minute Postprandial Blood Glucose and Insulin, 120-minute Postprandial Blood Glucose and Insulin. | through study completion, an average of 2 year |
| D009750 |
| Nutritional and Metabolic Diseases |