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The main purpose of this study is to compare the impact of concurrent high-intensity interval training (HIIT) and whole-body electromyostimulation exercise (WB-EMS) or low-volume conventional strength training (CST) on the cardiometabolic risk profile, overall physical fitness (cardiorespiratory fitness and muscular strength), body composition, inflammatory markers and subjective health outcomes after a 12-week intervention trial in overweight individuals at increased cardiometabolic risk. Furthermore, this study aims to investigate the influence of intra-session exercise order on all outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HIIT + WB-EMS | Experimental | High-intensity interval training (HIIT) combined with whole-body electromyostimulation (WB-EMS) Sequence of application: HIIT - WB-EMS |
|
| WB-EMS + HIIT | Experimental | Whole-body electromyostimulation (WB-EMS) combined with High-intensity interval training (HIIT) Sequence of application: WB-EMS - HIIT |
|
| HIIT + CST | Experimental | High-intensity interval training (HIIT) combined with conventional low-volume strength training (CST) Sequence of application: HIIT - CST |
|
| CST + HIIT | Experimental | Conventional low-volume strength training (CST) combined with high-intensity interval training (HIIT) Sequence of application: CST - HIIT |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HIIT + WB-EMS | Other | 12-week supervised exercise program consisting of ergometer-based high-intensity interval training (HIIT) and whole-body electromyostimulation (WB-EMS). HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. WB-EMS: Simulanteous stimulation of all major muscle groups with dedicated individual intensity. 2 exercise sessions per week. Order of application: HIIT - WB-EMS. Additionally, participants receive individualized nutritional counseling. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Metabolic Syndrome Z-Score (MetS-Z-Score). | MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex. | 12 weeks |
| Change in overall Physical Fitness Score (PFS) | PFS is calculated from VO2max and 1 Repmax values of 5 major muscle Groups. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Body Composition | Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA) | 12 weeks |
| Change in HOMA-IR | Insulin resistance will be estimated using homeostasis model assessment index (HOMA) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dejan Reljic, Dr. | Contact | +49 9131 8545218 | dejan.reljic@uk-erlangen.de | |
| Yurdaguel Zopf, Prof. | Contact | +49 9131 8545218 | yurdaguel.zopf@uk-erlangen.de |
| Name | Affiliation | Role |
|---|---|---|
| Dejan Reljic, Dr. | University Erlangen Nuremberg Medical School | Principal Investigator |
| Yurdaguel Zopf, Prof. | University Erlangen Nuremberg Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg | Recruiting | Erlangen | 91052 | Germany |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| C020556 | galactosylceramide sulfotransferase |
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Parallel Assignment parallel-group, randomized-controlled study
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Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking).
|
| WB-EMS + HIIT | Other | 12-week supervised exercise program consisting of whole-body electromyostimulation (WB-EMS) and ergometer-based high-intensity interval training (HIIT). WB-EMS: Simulanteous stimulation of all major muscle groups with dedicated individual intensity. HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. 2 exercise sessions per week. Order of application: WB-EMS - HIIT. Additionally, participants receive individualized nutritional counseling. |
|
| HIIT + CST | Other | 12-week supervised exercise program consisting of ergometer-based high-intensity interval training (HIIT) and conventional low-volume strength training(CST). HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. CST: Conventional 1-set strength training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. 2 exercise sessions per week. Order of application: HIIT - CST. Additionally, participants receive individualized nutritional counseling. |
|
| CST + HIIT | Other | 12-week supervised exercise program consisting of conventional low-volume strength training(CST) and ergometer-based high-intensity interval training (HIIT). CST: Conventional 1-set strength training using weight machines to train all major muscle groups with an individual intensity corresponding to 70-80% of one repetition maximum. HIIT: 5x1 min at 85-95% HRmax divided by low-intensity recovery periods. 2 exercise sessions per week. Order of application: CST - HIIT. Additionally, participants receive individualized nutritional counseling. |
|
| 12 week |
| Change Inflammation status | Inflammation will be assessed by measuring levels of inflammatory blood markers (CRP, inflammatory cytokines) | 12 weeks |
| Change in Health-related quality of life | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire | 12 weeks |
| Change in Pain scores | Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ) | 12 weeks |
| Change in Perceived stress | Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ) | 12 weeks |
| Change Subjective work ability | Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI) | 12 weeks |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D010335 | Pathologic Processes |