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The main purpose of this study is to compare the effects of whole-body electromyostimulation versus a conventional low-volume strength-training program, each combined with an individualized, weight-reducing diet, on the cardiometabolic risk profile, muscle strength, body composition, inflammatory markers and subjective health outcomes in overweight individuals at increased cardiometabolic risk.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Experimental | Nutritional therapy / no exercise |
|
| Standard Strength Training | Experimental | Nutritional therapy combined with a Standard Strength Training program |
|
| Low-volume Strength Training | Experimental | Nutritional therapy combined with a low-volume Strength Training program |
|
| Whole-body Electromyostimulation | Experimental | Nutritional therapy combined with Whole-Body Electromyostimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control | Other | Individualized, weight-reducing nutritional therapy and counseling, during a study period of 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Metabolic Syndrome Z-Score (MetS-Z-Score) | MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex. | 12 weeks (baseline to 12 week follow-up assessment) |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength | Muscle strength of the five major muscle groups (chest, upper back, lower back, abdominals, legs) will be assessed by using specific strength-training devices (Butterfly, Pull-down, Hyperextension, Abdominal Crunch, Leg-Press) | 12 weeks (baseline to 12 week follow-up assessment) |
| Body Composition |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dejan Reljic, Dr. | Contact | +49 9131 8545218 | dejan.reljic@uk-erlangen.de | |
| Yurdaguel Zopf, Prof. | Contact | +49 9131 8545218 | yurdaguel.zopf@uk-erlangen.de |
| Name | Affiliation | Role |
|---|---|---|
| Dejan Reljic, Dr. | University Erlangen Nuremberg Medical School | Principal Investigator |
| Yurdaguel Zopf, Prof. | University Erlangen Nuremberg Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, | Recruiting | Erlangen | 91052 | Germany |
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parallel-group, randomized-controlled study
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Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking).
| Standard Strength Training | Other | Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with a standard strength training program:
|
|
| Low-volume Strength Training | Other | Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined a low-volume strength training program:
|
|
| Whole-Body Electromyostimulation (WB-EMS) | Other | Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with WB-EMS:
|
|
Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA) |
| 12 weeks (baseline to 12 week follow-up assessment) |
| Cardiorespiratory Fitness (CRF) | CRF will be assessed by measuring Maximum Oxygen uptake (VO2max) | 12 weeks (baseline to 12 week follow-up assessment) |
| Inflammation status | Inflammation will be assessed by measuring Levels of CRP and inflammatory cytokines and other inflammatory blood markers | 12 weeks (baseline to 12 week follow-up assessment) |
| Health-related quality of life | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire | 12 weeks (baseline to 12 week follow-up assessment) |
| Pain scores | Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ) | 12 weeks (baseline to 12 week follow-up assessment) |
| Perceived stress | Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ) | 12 weeks (baseline to 12 week follow-up assessment) |
| Subjective work ability | Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI) | 12 weeks (baseline to 12 week follow-up assessment) |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D009043 | Motor Activity |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
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