This study aims to establish a large sample cohort of patients with primary sjogren's syndrome, collect multi-omics information of patients with primary sjogren's syndrome, and construct disease diagnosis model and disease prognosis prediction model.

Inclusion Criteria:

• Meets the 2002 AECG or 2016 ACR/EULAR classification criteria of primary Sjögren's syndrome.

Exclusion Criteria:

• Comorbid connective tissue disease other than the disease under research.
• Women who are pregnant or breastfeeding.
• Combined severe cardiovascular or cerebrovascular disease, hepatic or renal failure, or severe malignant tumors.
• Other conditions (e.g., cognitive impairment) that the investigators consider ineligible for enrollment.

Patients with primary Sjögren's syndrome