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| Name | Class |
|---|---|
| Concerted Research Action | UNKNOWN |
| Fonds National de la Recherche Scientifique | OTHER |
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Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.
In this monocenter interventional study, we will assess the impact of physical activity on muscle fat content and liver disease severity in MASLD as well as the mechanisms mediating the potential beneficial effects of exercise.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Active Comparator | in this control group, patients will perform non-cardiovascular non-intensity training (stretching, meditation). |
|
| moderate-intensity low interval training group | Active Comparator | In this group, patients will perform moderate-intensity low interval training. |
|
| high-intensity interval training | Active Comparator | In this group, patients willp erform high-intensity interval training. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-intensity interval training | Other | High-intensity interval training |
|
| Measure | Description | Time Frame |
|---|---|---|
| the impact of physical activity on muscle and liver phenotypes | the investigators will assess at baseline and every four weeks till study completion the impact of intervention on liver phenotype assessed by transient elastography and muscle phenotype assessed by MRI | every four weeks from baseline till study completion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guillaume Henin, MD, PhD student | Contact | 0032494312548 | guillaume.henin@uclouvain.be | |
| Nicolas Lanthier, MD, PhD | Contact | 003227647089 | nicolas.lanthier@saintluc.uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Nicolas Lanthier, MD, PhD | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques universitaires Saint-Luc | Brussels | 1200 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38322420 | Result | Henin G, Loumaye A, Leclercq IA, Lanthier N. Myosteatosis: Diagnosis, pathophysiology and consequences in metabolic dysfunction-associated steatotic liver disease. JHEP Rep. 2023 Nov 14;6(2):100963. doi: 10.1016/j.jhepr.2023.100963. eCollection 2024 Feb. | |
| 38623714 | Result | Henin G, Loumaye A, Deldicque L, Leclercq IA, Lanthier N. Unlocking liver health: Can tackling myosteatosis spark remission in metabolic dysfunction-associated steatotic liver disease? Liver Int. 2024 Aug;44(8):1781-1796. doi: 10.1111/liv.15938. Epub 2024 Apr 16. |
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Patients presenting both MASLD and an excessive muscle lipid content (myosteatosis) assessed by magnetic resonance imaging will be recruited. All patients will then be randomized in three groups corresponding to three physical activity programs of increasing intensity.
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| Moderate intensity exercise training | Other | Moderate intensity exercise training |
|
| Low intensity exercise training | Other | Low intensity exercise training |
|
| Centre d'investigation clinique en nutrition | Louvain-la-Neuve | 1348 | Belgium |
|
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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