Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Altitude training has been suggested to be of potential support to improve some chronic clinical conditions, especially metabolic conditions. Normobaric hypoxia represents a promising system to simulate altitude training, and its efficacy and safety have been suggested in different conditions, including diabetes, obesity and hypertension. Metabolic dysfunction-associated steatotic liver disease (MASLD) can characterized by metabolic alterations (including altered body composition, lipid and glycemic profile, etc.), and might benefit from aerobic training performed in simulated altitude training (i.e., normobaric hypoxia). Mild altitude training will be proposed (equal to about 2'500 m, 15% FiO2) and compared to a sham normobaric normoxia condition, during an 8-week 3 or 2 times per week 1-h aerobic training (walking) at 60-65% of maximum heart rate (HRmax). Cardiorespiratory fitness, body composition, and metabolic profile will be investigated.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HYPOTRAIN | Experimental | This arm will perform the normobaric hypoxic aerobic training (HYPOTRAIN) |
|
| NORMOTRAIN | Sham Comparator | This arm will perform the normobaric normoxia aerobic training (NORMOTRAIN) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HYPOTRAIN | Other | 8 weeks of 2/3 times per week, 1-h aerobic training (walking on a treadmill at 60-65% HRmax) while wearing a mask and air is delivered between 15 and 16 FiO2% |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body mass (kg) | Evaluation of changes in body mass measured on a scale | At the beginning of the study and after 8 weeks of training |
| Fat mass (%) | Evaluation of changes in fat mass, as percentage of body mass, assessed with bioimpedence (BIA) | At the beginning of the study and after 8 weeks of training |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum oxygen uptake (mL/kg*min) | Maximum oxygen uptake (VO2 max) assessed during a cardiopulmonary exercise test (CPET) | At the beginning of the study and potentially after 8 weeks of training |
| Liver markers |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Trieste - Exercise Physiology and Kinesiology Lab | Recruiting | Trieste | Trieste | 34100 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35563600 | Background | Luo Y, Chen Q, Zou J, Fan J, Li Y, Luo Z. Chronic Intermittent Hypoxia Exposure Alternative to Exercise Alleviates High-Fat-Diet-Induced Obesity and Fatty Liver. Int J Mol Sci. 2022 May 6;23(9):5209. doi: 10.3390/ijms23095209. | |
| 29923910 | Background | DE Groote E, Britto FA, Bullock L, Francois M, DE Buck C, Nielens H, Deldicque L. Hypoxic Training Improves Normoxic Glucose Tolerance in Adolescents with Obesity. Med Sci Sports Exerc. 2018 Nov;50(11):2200-2208. doi: 10.1249/MSS.0000000000001694. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000860 | Hypoxia |
| D009043 | Motor Activity |
| C564245 | Platelet Glycoprotein IV Deficiency |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| NORMOTRAIN | Other | 8 weeks of 2/3 times per week, 1-h aerobic training (walking on a treadmill at 60-65% HRmax) while wearing a mask and air is delivered between at normal (around 21) FiO2% |
|
Markers of liver health including ultrasound evaluation
| At the beginning of the study and after 8 weeks of training |
| Ventilatory threshold (mL/kg*min) | Metabolic intensity at which the ventilatory threshold occurs, as measured during the cardiopulmonary exercise test (CPET) | At the beginning of the study and potentially after 8 weeks of training |
| Triglyceride (mg/dL) | Blood triglyceride concentration | At the beginning of the study and after 8 weeks of training |
| Total cholesterol (mg/dL) | Blood total cholesterol concentration | At the beginning of the study and after 8 weeks of training |
| High-density lipoprotein (mg/dL) | Blood high-density lipoprotein concentration | At the beginning of the study and after 8 weeks of training |
| Low-density lipoprotein (mg/dL) | Blood low-density lipoprotein concentration | At the beginning of the study and after 8 weeks of training |
| C-reactive protein (mg/dL) | Blood c-reactive protein concentration | At the beginning of the study and after 8 weeks of training |
| Glycemia (mg/dL) | Blood glucose concentration | At the beginning of the study and after 8 weeks of training |
| Insulinemia (mg/dL) | Blood insulin concentration | At the beginning of the study and after 8 weeks of training |