Drug: Anti R-IL2 + Cyclosporine

• Anti R-IL2 induction (Simulect ®, 20 mg D0 and D4)
• Mycophenolate Mofetil (Cellcept ®) 3 grams per day beginning at D0
• Cyclosporine A (Neoral ®) started from 6 to 8 mg/kg adjusted to C2
• Corticosteroids 250 mg IV before and after surgery, then 1 mg/kg one week and 20mg/j the week after, then tapered until 10 mg/j at M1, 5 mg at M3 and stop between M4 and M6

Drug: Thymoglobulin + Everolimus

• Thymoglobulin ® induction started at 1.5mg/kg/j then adjusted to CD2 or total lymphocytes count, for 5 days
• Mycophenolate Mofetil (Cellcept ®) 3 grams per day beginning at D0
• Everolimus (Certican ®): 4 to 6 mg/day started at D5, adjusted to achieve a residual level between 6 et 10 ng/ml
• Corticosteroids 250 mg IV before and after surgery, then 1 mg/kg one week and 20mg/j the week after, then tapered until 10 mg/j at M1, 5 mg at M3 and stop between M4 and M6

Drug: Anti R-IL2 + Cyclosporine then Everolimus

• Anti R-IL2 induction (Simulect ®, 20 mg D0 and D4)
• Mycophenolate Mofetil (Cellcept ®) 3 g/d beginning at D0
• Cyclosporine A (Neoral ®) beginning at 6 to 8 mg/kg adjusted to C2, then switch to everolimus (Certican ®) between at W6, started at 3 mg/d, then adjusted to achieve a residual level between 6 et 10 ng/ml
• Corticosteroids 250 mg IV before and after surgery, then 1 mg/kg one week and 20mg/j the week after, then tapered until 10 mg/j at M1, 5 mg at M3 and stop between M4 and M6

Patient survival at last follow-up

Graft survival at last follow-up

Biopsy proven rejection

All infections requiring hospitalization