mTor-inhibitor (EVERolimus) Based Immunosuppressive Strategies for CNI Minimisation in OLD for Old Renal Transplantation

mTor-inhibitor (EVERolimus) Based Immunosuppressive Strategies for CNI Minimisation in OLD for Old Renal Transplantation

This study is designed to evaluate efficacity and safety of everolimus or (cyclosporine then everolimus) vs. cyclosporine as immunosuppressive treatment in renal transplantation for elderly (>60 years old) recipients receiving graft from elderly donor(>60 years old).

Inclusion Criteria:

• Patient who has given written informed consent to participate in the study
• First or second single transplantation of a recipient (male or female) older than 60 years old
• Donor older than 60 years old
• PRA < 30%

Exclusion Criteria:

• Living donor
• Third transplantation
• PRA > 30%

Other protocol-defined inclusion/exclusion criteria may apply.

• Recipient of multi-organ transplant
• Active major infections (HBV, HCV, HIV)
• Loss of a first graft for immunologic issues
• Anemia (<9g/l) or leucopenia (<2500/mm3)