PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis

Effects of Probiotic Supplementation During the Neonatal Period on the Preterm Infant

The main objective of this study is to assess the impact of two different doses of a mixture of probiotics from two strains isolated in human milk on the incidence of severe necrotizing enterocolitis (NEC) and death among preterm infants of gestational age less than or equal to 32 weeks of gestation and weighing between 750 and 1500 g.

Inclusion Criteria:

• Preterm infants of gestational age less than 33 weeks of gestation with birth weight below 1500 g, admitted to the Neonatology Unit.
• Premature newborns who meet the above criteria and receive enteral feeding (mother breast milk, donors milk and/or premature formula) from the amount of 5 ml/kg/day.

Exclusion Criteria:

• Any clinical circumstance that prevents the initiation of enteral nutrition in the first 72 hours of life.
• Chromosomopathies and complex fetal malformations, incompatible with enteral nutrition in the first 72 hours of life.
• Non-acceptance of informed consent to participate in the study by the parents or legal guardians of the newborn.