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| Name | Class |
|---|---|
| National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov | OTHER_GOV |
| University Hospital Heidelberg | OTHER |
| Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques |
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Prospective cohort study investigating the menstrual cycle phase (MCP)-dependent incidence of acute mountain sickness (AMS) in women travelling to 3600 m.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women in luteal MCP | Women being in their luteal MCP on the day of ascent to high altitude. |
| |
| Women in follicular MCP | Women being in their follicular MCP on the day of ascent to high altitude. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure to 3600 m | Other | Participants will travel to and stay for 2 days at an altitude of 3600 m. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Acute Mountain Sickness (AMS) Incidence, LLS 2018 | MCP-related difference in the AMS incidence. AMS incidence will be defined as a Lake Louise Questionnaire version 2018 score of ≥3. | Day 1 to 3 at 3600 m |
| Measure | Description | Time Frame |
|---|---|---|
| Acute Mountain Sickness (AMS) Incidence, LLS 1993 | MCP-related difference in the AMS incidence. AMS incidence will be defined as a Lake Louise Questionnaire version 1993 score of ≥3. | Day 1 to 3 at 3600 m |
| Acute Mountain Sickness (AMS) Severity, LLS 2018 |
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Inclusion Criteria:
Exclusion Criteria:
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Healthy, non-smoking, premenopausal women, age 18-44 years, without any disease and need of regular medication (including oral contraceptives).
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| Name | Affiliation | Role |
|---|---|---|
| Michael Furian, Prof. Dr. | University of Zurich | Study Chair |
| Talant Sooronbaev, Prof. Dr. | National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Center for Cardiology and Internal Medicine | Bishkek | Bishkek | 720040 | Kyrgyzstan |
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| ID | Term |
|---|---|
| D000532 | Altitude Sickness |
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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MCP-related difference on the AMS severity assessed by the Lake Louise Questionnaire version 2018. |
| Day 1 to 3 at 3600 m |
| Acute Mountain Sickness (AMS) Severity, LLS 1993 | MCP-related difference on the AMS severity assessed by the Lake Louise Questionnaire version 1993. | Day 1 to 3 at 3600 m |
| Arterial blood gases | MCP-related difference on the arterial blood gases (pH, PaO2, PaCO2, SaO2). | Day 2 at 760 m and day 2 at 3600 m |
| Hypoxic ventilatory response | MCP-related difference in the hypoxic ventilatory response assessed under FiO2 of 0.115 and while cycling on a bicycle at 30% of predicted maximal work capacity. | Day 2 at 760 m |
| Perceived pain visualization | MCP-related difference on perceived pain sensations, visualized by the SMaRT tablet app | Day 1 to 3 at 3600 m |
| D013568 | Pathological Conditions, Signs and Symptoms |