HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men

HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men. A Randomized, Placebo-Controlled, Double-Blind Parallel Trial.

Randomized clinical trial evaluating the effect of acetazolamide on pulmonary artery pressure in women compared to men travelling to 3600 m.

Inclusion Criteria:

• Healthy, non-smoking men and women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives).
• BMI >18 kg/m2 and <30 kg/m2
• Born, raised and currently living at altitudes <1000 m
• Written informed consent
• Premenopausal women with an eumenorrheic cycle

Exclusion Criteria:

• Other types of contraceptvies (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others)
• Pregnancy or nursing
• Anaemic (haemoglobin concentration <10g/dl)
• Any altitude trip <4 weks before the study
• Allergy to acetazolamide and other sulfonamides