Psoriasis lesion is divided into two parts. Half of the lesion will apply cream containing sericin and turmeric and another will apply steroid cream (control). The samples will be apply two times a day for 8 weeks. Psoriasis area and severity index, physician global assessment, body surface area of lesion, dermatology life quality index, Itching score, adverse reaction are evaluated before, after using the samples for 4 and 8 weeks.

Inclusion Criteria:

• Age over 18 years
• Patients with body surface area of psoriasis lesion less than 10, have psoriasis area and severity index less than 10 , and no lesion at face, hands,feet, and genital area
• No topical application on psoriasis lesion at least 2 weeks
• Willing to attend the study

Exclusion Criteria:

• Uncontrolled diseases
• Allergic to sericin turmeric and steroid
• Other skin diseases
• Pregnancy and lactation