Safety of Cream Containing Sericin and Turmeric in Healthy Volunteers

Safety of Cream Containing Sericin and Turmeric in Healthy Volunteers

The object of this study was to evaluate safety of cream containing sericin and turmeric in healthy volunteers.

There are 106 healthy volunteers in this study. Upper left arm is divided into 2 parts (2x2 cm) which are A and B area. Upper right arm is divided into 2 parts (2x2 cm) which are C and D area. Four area (A, B, C, and D) are randomized to receive cream containing 2.5% sericin and 2%turmeric, cream containing 5%sericin and 2%turmeric, cream containing 10%sericin and 2%turmeric, and cream base (Control group). Samples are applied 2 times/day for 6 days (Induction phase). Then, the volunteers will stop applying samples for 7 to 10 days (Free period). After that, Samples are applied 2 times/day for 3 days (Challenge phase). Erythema, melanin, humidity, transepidermal water loss, skin adverse reaction, and satisfaction are evaluated.

Inclusion Criteria:

• Age 18 to 60 years
• No skin diseases
• No allergy to sericin and turmeric
• No immunocompromised disease or using steroid for 2 weeks before participated in this study
• Willing to participate in this study

Exclusion Criteria:

• Uncontrolled disease, cancer, and heart disease
• Cannot follow the protocol
• Pregnancy and lactation
• Participated in other studies