Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis

Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis: Multi-center, Double-blind, Randomized Controlled Trial

A randomized placebo-controlled clinical trial to evaluate efficacy of hyaluronic acid in prevention of acute radiation proctitis among oncology patient population especially who are diagnosed with abdomeno-pelvic tumors and subsequently required radiotherapy.

Inclusion Criteria:

• All patients diagnosed with pelvic or gastrointestinal malignancies (tumors in uterus, cervix, prostate, seminal vesicles, kidney, colon, etc.),
• All patients who required adjuvant or radical radiation therapy;
• Age < 80 years;
• Karnofsky Performance Status ≥ 60

Exclusion Criteria:

• Patients were excluded if they had

  • gt; previous pelvic radiotherapy,
  • gt; inflammatory bowel disease or
  • gt; rectal issues (e.g., haemorrhoids).

• Patients diagnosed with cancer rectum