To Evaluate the Technique and Effects of Separating the Prostate and Rectum With Hyaluronic Acid During Radiotherapy

Initiating Phase II-III Study to Evaluate the Technique and Effects of Separating the Prostate From the Rectum With Hyaluronic Acid During Radiotherapy

The dominating problem after local radiotherapy of prostate cancer is rectal toxicity. If the rectum could be completely moved out of the treated volume, a substantial decrease of rectal toxicity seems reasonable. In this study we will develop and evaluate a new transrectal injection technique where hyaluronic acid (HA) is injected in the space between the prostate and the rectum prior to external beam radiotherapy to increase the physical distance between prostate and rectum.

Inclusion Criteria:

• Histologically verified prostatic cancer
• Low or intermediate risk prostatic cancer
• Lymph node negative
• Suitable for radiotherapy

Exclusion Criteria:

• Earlier treatment for prostatic cancer
• Unable to co-operate or suffering from any other form of disease that would interfere with the planned treatment