Effects of Nutritional Support on Postoperative Delirium

Effects of Nutritional Support on Postoperative Delirium (POD) in Elderly Non-cardiac Surgical patients_non-inferiority Comparison

This study is a prospective, single-center, randomized controlled trial to compare whether applying nutritional supplementation therapy before and after surgery in elderly patients aged 65 years or older undergoing non-cardiac surgery can reduce the incidence of postoperative delirium.

Inclusion Criteria:

• Elderly patients aged 65 and above.
• Patients undergoing non-cardiac major surgery in thoracic surgery, lung cancer surgery, multi-level spinal surgery in neurosurgery and orthopedics, or liver cancer surgery in hepatobiliary and pancreatic surgery, under general anesthesia with an expected surgery duration of 2 hours or more.
• Patients scheduled for arterial catheterization.
• Patients who are able to take oral intake from postoperative day #1.

Exclusion Criteria:

• Patients with uncontrolled systemic conditions such as diabetes, hypertension, renal disease, liver disease, and other systemic illnesses.
• Those with visual impairment.
• Patients with cognitive impairment based on the Mini-Mental State Examination for Dementia Screening criteria.
• Individuals experiencing difficulty in communication.
• Those diagnosed with neurological disorders (such as brain hemorrhage, stroke, brain tumor, dementia, Parkinson's disease, cognitive impairment, depression, etc.).
• Patients diagnosed with alcohol or substance addiction.
• Patients with cancelled scheduled surgeries.
• Patients undergoing minor surgeries with expected anesthesia durations of less than 2 hours.