Research Into Diagnostic and Prognostic Molecular and Imaging Biomarkers of Ocular Disorders Associated With Neurovascular Deregulation: Biocor Cohort

Recherche de Biomarqueurs moléculaires et d'Imagerie Diagnostiques et Pronostiques Des Atteintes Oculaires associées à Des dérégulations Neurovasculaires : Cohorte Biocor

BIOCOR is an interventional clinical trial whose main objectives are Objectif are identify molecular biomarker(s) of ocular rosacea and pachychoroid. Endpoints are : Correlation between pachychoroidosis (defined by choroidal phenotype parameters in OCT and autofluorescence) or the stage of ocular rosacea (ROSCO(29) definition) and biological markers selected on the basis of preclinical work (animal model) and by unbiased methods (proteomics, metabolomics, meibum lipidomics). The study of circulating, ocular and functional biomarkers would enable us to confirm our hypothesis and identify patients who could benefit from treatments that regulate the ANS and/or mineralocorticoid pathways.

Inclusion Criteria:

• Male or female > 18 years of age, of European origin, with signed ± genetic consent
• Clear ocular media for OCT and autofluorescence imaging
• Signed consent form
• Be affiliated to a health insurance scheme
• Control patients are patients scheduled for cataract surgery or visual assessment.

Exclusion Criteria:

• High myopia > 6D
• Diabetic retinopathy, hereditary retinal dystrophy, untreated retinal detachment, choroidal ocular tumor, choroidal hemangioma
• Epithelial or stromal keratopathy other than ocular rosacea
• Corneal surgery less than 3 months old, keratoplasty
• Deprived of liberty or under guardianship or curatorship