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The aim of this study is to describe the clinical, meibographic and interferometric manifestations of phlyctenular keratitis in children.
The investigators are conducting a monocentric, transversal, epidemiologic study. 100 patients should be included: 50 children suffering from ocular rosacea, and 50 children with no palpebral or Meibomian disease. Witnesses will be matched on the age of the cases.
Patient and controls will undergo a classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, the child will go through a meibographic and interferometric evaluation of his two inferior eyelids. This evaluation is made by an optometrist with the Lipiview device, and lasts a few minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cases : suffering from ocular or oculo-cutaneous rosacea | Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device. |
| |
| Witnesses | Without any present or past palpebral meibomian Gland Dysfunction Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ophthalmologic examination and meibographic and interferometric evaluation (Lipiview device) | Procedure | Classic ophthalmologic examination with visual acuity measurement and slit lamp examination of both eyes and eyelids. Then, meibographic and interferometric evaluation of his two inferior eyelids with the Lipiview device. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical severity | Clinical severity is determined with a composite score, by the presence of chalazia, corneal lesions, neovascularization, phlyctena, loss of vision, superficial keratitis, anterior and posterior keratitis, meibomitis, palpebral margin keratinization, lagophthalmos, long term use of azithromycin treatment, treatment by ciclosporin eyedrops, intense cutaneous or ocular symptoms, long time evolution of the disease. | Day of inclusion |
| Meibographic severity | The meibographic severity is determined by the level of Meibomian gland atrophy, data obtained with the Lipiview | Day of inclusion |
| Interferometric severity | The interferometric severity is evaluated by the thickness of the lipid layer tear film, data obtained with the Lipiview | Day of inclusion |
| Number of abortive blinks | Number of abortive blinks during the Lipiview exam | Day of inclusion |
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Inclusion Criteria:
Exclusion Criteria:
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Children aged between 2 and 16 : Cases, suffering from ocular or oculo-cutaneous rosacea and Witnesses without any present or past palpebral or meibomian disease
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| Name | Affiliation | Role |
|---|---|---|
| Serge DOAN, MD | Fondation Ophtalmologique A. de Rothschild | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondation Ophtalmologique A. de Rothschild | Paris | 75019 | France |
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|
| ID | Term |
|---|---|
| D012393 | Rosacea |
| D007637 | Keratoconjunctivitis |
| D000080343 | Meibomian Gland Dysfunction |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D003231 | Conjunctivitis |
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
| D007634 | Keratitis |
| D003316 | Corneal Diseases |
| D005141 | Eyelid Diseases |
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