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This study is designed to evaluate and compare clinically and radiographically the effectiveness of Demineralized Dentin Allograft (DDA) versus Demineralized Dentin Autograft (Auto-DD) for preservation of alveolar ridge dimensions after surgical extraction of the impacted mandibular third molar.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | 20 sockets will be grafted with Demineralized Dentin Allograft (DDA) |
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| Group B | Active Comparator | 20 sockets will be grafted with Demineralized Dentin Autograft (Auto-DD) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Demineralized Dentin Allograft | Procedure | 20 sockets are randomly allocated to receive the Demineralized Dentin Allograft (split-mouth study) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measuring and comparing the height of bone between the two groups | We will measure the height of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation | Immediately post-operative, 3months post-operative, 6months post-operative |
| Measuring and comparing the width of bone between the two groups | We will measure the width of the alveolar ridge clinically by using ridge mapping caliper (special caliper forceps used for measuring ridge dimensions) and radiographically on the cone-beam computed tomography (CBCT) and comparing the results of the study group (20 sockets) with the control group (the other 20sockets), to assess the effectiveness of Demineralized Dentin Allograft for ridge preservation | Immediately post-operative, 3months post-operative, 6months post-operative |
| Measure | Description | Time Frame |
|---|---|---|
| Assess and comparing the mouth opening of both groups | Assess the mouth opening of the patient using a millimeter ruler (by measuring the distance between maxillary incisal edge and mandibular incisal edge) and comparing the results of both groups | One day post-operative, one week post-operative |
| Assess and comparing the swelling of both groups |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mohamed Habib, B.D.S | Contact | +2001069505336 | mbasiouny@horus.edu.eg | |
| Ahmed Khalil, PHD | Contact | +2001005062045 | akhalil@horus.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Mohamed Habib, B.D.S | Faculty of Dentistry- Horus University in Egypt | Principal Investigator |
| Ahmed Khalil | Faculty of Dentistry- Horus University in Egypt | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry- Horus University in Egypt | Damietta | New-Damietta | 34518 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28839405 | Background | Joshi CP, D'Lima CB, Samat UC, Karde PA, Patil AG, Dani NH. Comparative Alveolar Ridge Preservation Using Allogenous Tooth Graft versus Free-dried Bone Allograft: A Randomized, Controlled, Prospective, Clinical Pilot Study. Contemp Clin Dent. 2017 Apr-Jun;8(2):211-217. doi: 10.4103/ccd.ccd_147_17. | |
| 22048602 | Background |
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| ID | Term |
|---|---|
| D016301 | Alveolar Bone Loss |
| ID | Term |
|---|---|
| D001862 | Bone Resorption |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D055093 | Periodontal Atrophy |
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| ID | Term |
|---|---|
| C000849 | bis(p-chlorophenyl)acetic acid |
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20 sockets will be grafted with Demineralized Dentin Allograft (DDA) and 20 sockets will be grafted with Demineralized Dentin Autograft (Auto-DD)
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| Demineralized Dentin Autograft | Procedure | 20 sockets are randomly allocated to receive the Demineralized Dentin Autograft (split-mouth study) |
|
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Swelling levels after surgery will be measured using anatomic landmarks (Tragus-Labial commissure and Tragus-Pogonion), the distances between the landmarks used for the evaluation methods will be measured before the operation. All measurements will be done using millimeter ruler, while the patient will be seated. |
| One day post-operative, one week post-operative |
| Assess and comparing the pain of both groups | we will use the Visual Analogue Scale (VAS) for pain measurement | One day post-operative, one week post-operative |
| Assess and comparing the soft tissue parameters (bleeding on probing and color of the gingiva) of both groups | The bleeding on probing will be assessed by using periodontal probe and this will be done around mandibular first and second molars | One day post-operative, one week post-operative |
| Eman Abdelsalam |
| Faculty of Dentistry- Horus University in Egypt |
| Study Director |
| Grover V, Kapoor A, Malhotra R, Sachdeva S. Bone allografts: a review of safety and efficacy. Indian J Dent Res. 2011 May-Jun;22(3):496. doi: 10.4103/0970-9290.87084. |
| D010510 |
| Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |