Comparison of Autogenous Dentin Matrix Versus Bovine-Derived Xenograft for Socket Preservation

Clinical, Radiographic and Histomorphometric Comparison of Autogenous Demineralized Dentin Matrix Versus Bovine-Derived Xenograft for Socket Preservation: A Randomised Controlled Clinical Trial

The present study is a human, prospective, randomised controlled clinical trial will be conducted to explore and compare the clinical, radiographic and histomorphometric outcome of autogenous demineralised dentin(DDM) versus bovine derived xenograft(DBM) for socket preservation procedure.

• After local anesthesia a full thickness flap will be minimally reflected buccally and lingually around the tooth not exceeding 3mm apical to the alveolar crest.
• Tooth extraction will be performed using atraumatic extraction methods using Periotome.
• After extraction, the socket will be thoroughly curetted, inspected and irrigated with sterile saline solution.
• The socket satisfying the inclusion and exclusion criteria will be randomly allocated to either test or control group.
• Intra surgical measurements will be recorded.
• Socket preservation will be performed with either Demineralized dentin matrix DDM(TEST) or bovine derived xenograft DBM (CONTROL). Bone graft will be extended to the height of intra proximal bone.
• Collagen membrane will be placed over the grafted site extending approximately 3mm apical to buccal and lingual crest.
• Flaps will be approximated with sutures.

Inclusion Criteria:

• Teeth indicated for extraction and subsequent implant placement
• Age group of 18 to 55 years
• Single rooted tooth indicated for extraction due to endodontic failure, caries or Fracture
• Presence of >2 mm keratinized tissue to allow flap management
• Extraction site should have adjacent tooth on either side
• Systemically healthy patients
• Class II or III extraction socket defects according to Hammerele and Jung(2008)
• Full mouth plaque score(FMPS)<25% at baseline.(PI)
• Full mouth bleeding score(FMBS)<25% at baseline. (BI)

Exclusion Criteria:

• .Presence of dehiscence or fenestration in any of the socket, more than 50% of bone loss in any of the socket walls
• Medical conditions contraindicating surgical interventions
• Known smokers and alcoholics
• Subjects with known bone metabolic disorders.(Pagets disease,fibrous dysplasia etc.)
• Acute infections at the site of extraction. Eg , Abscess
• History of malignancy
• Patients who have undergone radiotherapy or chemotherapy
• Periapical pathology such as granulomas, cyst, hypercementosis, ankylosis.
• Pregnant and lactating women
• Maxillary and mandibular 3rd molars.