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Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
Aims: To compare functional (visual acuity and refractive error) and anatomical (biometric values, foveal and choroidal thickness) ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity (ROP).
Settings and Design: Prospective Cross-Sectional Study
Methods and Material: The study was conducted prospectively in the ophthalmology department of Ankara Bilkent City Hospital. Subjects were divided into three groups: 29 children who were treated with laser photocoagulation (ROP-TxGroup), 26 children who developed ROP and did not need treatment (ROP-non-TxGroup), and 25 children who did not develop ROP (Premature Group). The 27 healthy children with a history of full-term born (Control Group), who were in a similar age group for 'control eye examination', were accepted as the control group. A total of 107 patients and 211 eyes were included in the study. Non-cycloplegic and cycloplegic refraction, best corrected visual acuity (BCVA), keratometry, axial length (AL) and anterior chamber depth (ACD), optical coherence tomography (OCT) macular and OCT subfoveal choroidal measurements were performed in all cases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ROP-Tx Group | less than 37 weeks were divided into three groups: 29 children born prematurely who were treated with laser photocoagulation |
| |
| ROP-non-Tx Group | 26 children who developed ROP and did not need treatment |
| |
| Premature Group | 25 children who did not develop ROP |
| |
| Control Group | 27 healthy children with a history of full-term born |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT) | Device | Non-cycloplegic and cycloplegic refraction, best corrected visual acuity (BCVA), axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT) macular and OCT subfoveal choroidal measurements were performed in all cases. |
| Measure | Description | Time Frame |
|---|---|---|
| Spherical Equivalents | Dioptre | 4mounth after the procedure |
| K1 Flat and K2 Steep | Dioptre | 4mounth after the procedure |
| Axial Length | Milimeter | 4mounth after the procedure |
| Anterior Chamber Depth | Milimeter | 4mounth after the procedure |
| Astigmatism | Dioptre | 4mounth after the procedure |
| Best Corrected Visual Acuity | logMAR | 4mounth after the procedure |
| Macular and Choroidal Thickness | Micrometer | 4mounth after the procedure |
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Inclusion Criteria:
Children with a history of ROP
Exclusion Criteria:
Stage 4-5 ROP, Presence of media opacities (such as cataract) Ocular trauma or ocular surgery Hydrocephalus or grade 3 and above intracerebral hemorrhage, Uncooperative children
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The files of babies born between 2008 and 2016 and taken for ROP scan in the ophthalmology department were randomly separated by archive scanning. International Classification of Retinopathy of Prematurity (ICROP) was used as classification criteria. Although ICROP was used as screening criteria, every patient suspected by the paediatrician was examined. When the children of the volunteer families reached the age of 5-13, their children were called for examination.
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| Name | Affiliation | Role |
|---|---|---|
| Ali Kutay KILINÇ | Ankara City Hospital Bilkent | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ankara City Hospital Bilkent | Ankara | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D012178 | Retinopathy of Prematurity |
| D009216 | Myopia |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| D005128 | Eye Diseases |
| D007235 | Infant, Premature, Diseases |
| D007232 | Infant, Newborn, Diseases |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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|
|
| D009358 |
| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D012030 | Refractive Errors |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D012107 | Research Design |
| D008722 | Methods |