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The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.
Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients with anxiety | Patients in this group suffered from herpes zoster neuralgia and had a score more than or equal to 8 for Hospital Anxiety and Depression Scale- Anxiety questionnaire. |
| |
| patients without anxiety | Patients in this group suffered from herpes zoster neuralgia and had a score less than 8 for Hospital Anxiety and Depression Scale- Anxiety questionnaire. |
| |
| patients with depression | Patients in this group suffered from herpes zoster neuralgia and had a score more than or equal to 8 for Hospital Anxiety and Depression Scale- Depression questionnaire. |
| |
| patients without depression | Patients in this group suffered from herpes zoster neuralgia and had a score less than 8 for Hospital Anxiety and Depression Scale- Depression questionnaire. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hospital Anxiety and Depression Scale | Diagnostic Test | Hospital Anxiety and Depression Scale questionnaire is used to test patients for anxiety and depression. |
|
| Measure | Description | Time Frame |
|---|---|---|
| HADS score | Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression. | during hospital stay, average of 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Interleukin (IL）-1β plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-1β （pg/ml）will be tested. | during hospital stay, average of 1 week |
| IL-2 receptor plasma level |
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Inclusion Criteria:
Exclusion Criteria:
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This study will be conducted in patients who are diagnosed as herpes zoster neuralgia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yang Shuguang, M.D | Contact | （+86）15071078161 | yangsuperpro@163.com | |
| Mei wei, M.D, PhD | Contact | (+86)13006162508 | wmei@hust.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Yang Shuguang, M.D | Tongji medical college of Huazhong University of Science and technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tongji hospital | Recruiting | Wuhan | Hubei | 430031 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33326962 | Background | Du J, Sun G, Ma H, Xiang P, Guo Y, Deng Y, Li S, Li X. Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study. Dermatology. 2021;237(6):891-895. doi: 10.1159/000512190. Epub 2020 Dec 16. |
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no plan to make individual participant data (IPD) available to other researchers
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| ID | Term |
|---|---|
| D006562 | Herpes Zoster |
| D001008 | Anxiety Disorders |
| D003863 | Depression |
| D009437 | Neuralgia |
| ID | Term |
|---|---|
| D000073618 | Varicella Zoster Virus Infection |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
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Serum is obtained to test for biomarkers
Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-2 （u/ml）will be tested.
| during hospital stay, average of 1 week |
| IL-6 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-6 （pg/ml）will be tested. | during hospital stay, average of 1 week |
| IL-8 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-8 （pg/ml）will be tested. | during hospital stay, average of 1 week |
| IL-10 plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-10 （pg/ml）will be tested. | during hospital stay, average of 1 week |
| Interferon(INF)-α plasma level | Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines INF-α （pg/ml）will be tested. | during hospital stay, average of 1 week |
| Brain-derived neurotrophic factor (BDNF) plasma level | Blood sample will be obtained from enrolled patients and the plasma level of BDNF（pg/ml）will be tested. | during hospital stay, average of 1 week |
| C-reactive protein (CRP) plasma level | Blood sample will be obtained from enrolled patients and the plasma level of CRP（mg/ml）will be tested. | during hospital stay, average of 1 week |
| Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging | Functional brain magnetic resonance imaging will be performed in patients with anxiety or depression, and area under curve (AUC) of topological metrics including Eglob,Eloc,Cp,Lp,γ,λ and σ will be calculated and analyzed. | during hospital stay, average of 1 week |
| D007239 | Infections |
| D001523 | Mental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |