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Occurrence of unforeseen study issues and a presence of unanticipated risks that cannot be adequately quantified.
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| Name | Class |
|---|---|
| Janssen Scientific Affairs, LLC | INDUSTRY |
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This study is being done to find out if a non-invasive Magnetic Resonance Imaging (MRI) examination of the kidneys may be helpful in patients with systemic lupus erythematosus (SLE).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Known Lupus Nephritis, with elevated UPCR result | Patients will have one scan at baseline, and one every 4 weeks thereafter for 3 visits. The final imaging session is after 6 months of routine therapy. | ||
| No known lupus nephritis | Patients will have one MRI | ||
| Known Lupus Nephritis, with normal Urine Protein Creatinine Ratio (UPCR) result | Patients will have one scan at baseline, and one every 4 weeks thereafter for 3 visits. |
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| Measure | Description | Time Frame |
|---|---|---|
| Presence of inflammation | The presence of inflammation within both kidneys will be measured using MRI. | Six months |
| Presence of fibrosis | The presence of fibrosis within both kidneys will be measured using MRI. | Six months |
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Inclusion Criteria:
Exclusion Criteria:
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Specialty clinic
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| Name | Affiliation | Role |
|---|---|---|
| Homa Timlin, MD, MSc, MRCP, CCST | Johns Hopkins School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | United States |
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| ID | Term |
|---|---|
| D008180 | Lupus Erythematosus, Systemic |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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