Tunisian Clinical Registry on Hypoparathyroidism and Pseudo-hypoparathyroidism

Tunisian Clinical Registry on Hypoparathyroidism and Pseudo-hypoparathyroidism

Observational, multicenter, national, cross-sectional study aiming to describe the epidemiological clinical, biological and therapeutic profile of patients suffering from defect in secretion (hypoparathyroidism) or action (pseudo-hypoparathyroidism) of parathyroid hormone.

Endocrinologists from both sectors (public and private) are participating in the study. Data will be captured electronically by DACIMA Clinical Suite, according to FDA 21 CFR part 11 (Food and Drug Administration 21 Code of Federal Regulations part 11), HIPAA (Health Insurance Portability and Accountability Act) & ICH (International Conference on Harmonisation) requirements.

Inclusion Criteria:

• Hypoparathyroidism defined by low serum calcium < 2.2 mmol/l (< 88 mg/l) associated with inadequate PTH (low or normal) and normal creatinine

Exclusion Criteria:

• Cervical surgery < 6 months.
• Transient (neonatal, etc.) or functional (dysmagnesemia, etc.) hypoparathyroidism.
• Other causes of hypocalcemia: vitamin D deficiency, chronic renal failure, etc.
• Familial hypocalcemia hypercalciuria.
• Pseudo-pseudo-hypoparathyroidism.