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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01AA030548-01 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NIH |
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The goal of this experiment is to examine responses to alcohol warning messages about 10 different topics among US adult alcohol consumers. The main questions this experiment aims to answer are:
Which warning topics make alcohol consumers in the US want to drink less alcohol? Which warning topics remind alcohol consumers in the US of alcohol's harms? Which warning topics help alcohol consumers in the US learn something new? There will be a total of 20 alcohol messages, 2 messages for each of the 10 topics. For each topic, participants will be randomly assigned to 1 of the 2 messages so that they view a total of 10 alcohol messages. All 10 messages will be shown in random order. Participants will rate each message on how much it makes them want to drink less alcohol, reminds them that drinking can be harmful, and teaches them something new.
This study aims to determine which topics in alcohol warning labels are most effective at making US adults who consume alcohol want to drink less alcohol, which topics best remind consumers of alcohol's harms, and which topics are most likely to teach consumers something new. The survey research company NORC at the University of Chicago will recruit a sample of 1,000 US adults ages 21+ who consumed alcohol at least one time per week during the past 4 weeks.
Participants will complete a within-subjects online randomized experiment in which they view and rate messages shown on alcohol containers. Participants will rate each message on perceived message effectiveness (primary outcome), reminding of alcohol's harms (secondary outcome), and learning something new (secondary outcome). These tasks will be repeated for 10 messages, each with a different topic. There will be 9 warning topics (i.e., topics about alcohol's harms) and 1 control topic (i.e., neutral topic not about alcohol's harms). In this within-subjects experiment, the survey will present the topics in random order and participants will view 1 of 2 messages for each topic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alcohol Messages | Experimental | Participants will view and rate 10 messages shown on alcohol containers. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Liver Cancer | Behavioral | Participants will view messages about the risk of liver cancer from alcohol consumption. |
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| Measure | Description | Time Frame |
|---|---|---|
| Perceived Message Effectiveness | The study will assess perceived message effectiveness using 1 item: "How much does this message make you want to drink less alcohol?" Response options will range from "not at all" (coded as 1) to "a great deal" (coded as 5). Higher scores indicate more perceived message effectiveness. Survey weighted means are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. | Assessed during one-time 15-minute online study survey |
| Measure | Description | Time Frame |
|---|---|---|
| Reminding of Alcohol's Harms | The study will assess reminding of alcohol's harms using 1 item: "How much does this message remind you that drinking alcohol can be harmful?" Response options will range from not at all (1) to a great deal (5). Higher scores indicate greater reminding of alcohol's harms. Survey weighted means are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marissa Hall, PhD | University of North Carolina, Chapel Hill | Principal Investigator |
| Anna Grummon, PhD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of North Carolina | Chapel Hill | North Carolina | 27599 | United States |
Investigators will post de-identified individual participant data in a public repository.
Investigators will post individual participant data upon acceptance of any manuscripts associated with the data generated in this study.
Data and code will be made publicly available.
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| ID | Title | Description |
|---|---|---|
| FG000 | Alcohol Messages | Participants will view and rate 10 messages shown on alcohol containers. Liver Cancer: Participants will view messages about the risk of liver cancer from alcohol consumption. Throat and Mouth Cancer: Participants will view messages about the risk of throat and mouth cancer from alcohol consumption. Colorectal Cancer: Participants will view messages about the risk of colorectal cancer from alcohol consumption. Multiple Cancers: Participants will view messages about the risk of multiple cancers from alcohol consumption. Liver Disease: Participants will view messages about the risk of liver disease from alcohol consumption. Hypertension: Participants will view messages about the risk of hypertension from alcohol consumption. Dementia: Participants will view messages about the risk of dementia from alcohol consumption. Drinking Guidelines: Participants will view messages about guidelines for alcohol consumption. Current Warning: Participants will view the current warning that is required on most alcoholic beverage containers sold in the US. Control: Participants will view neutral messages unrelated to the harms of alcohol consumption. |
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| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Alcohol Messages | Participants will view and rate 10 messages shown on alcohol containers. Liver Cancer: Participants will view messages about the risk of liver cancer from alcohol consumption. Throat and Mouth Cancer: Participants will view messages about the risk of throat and mouth cancer from alcohol consumption. Colorectal Cancer: Participants will view messages about the risk of colorectal cancer from alcohol consumption. Multiple Cancers: Participants will view messages about the risk of multiple cancers from alcohol consumption. Liver Disease: Participants will view messages about the risk of liver disease from alcohol consumption. Hypertension: Participants will view messages about the risk of hypertension from alcohol consumption. Dementia: Participants will view messages about the risk of dementia from alcohol consumption. Drinking Guidelines: Participants will view messages about guidelines for alcohol consumption. Current Warning: Participants will view the current warning that is required on most alcoholic beverage containers sold in the US. Control: Participants will view neutral messages unrelated to the harms of alcohol consumption. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Customized | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Perceived Message Effectiveness | The study will assess perceived message effectiveness using 1 item: "How much does this message make you want to drink less alcohol?" Response options will range from "not at all" (coded as 1) to "a great deal" (coded as 5). Higher scores indicate more perceived message effectiveness. Survey weighted means are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. | This study compares the message effectiveness of the topic message to the control message. Messages within each topic were not compared to one another. | Posted | Mean | Standard Error | score on a scale | Assessed during one-time 15-minute online study survey |
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Adverse Events were not monitored/assessed for this one-time online survey study.
All-Cause Mortality, Serious, and Other [Not Including Serious] Adverse Events were not monitored/assessed for the study.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Alcohol Messages | Participants will view and rate 10 messages shown on alcohol containers. Liver Cancer: Participants will view messages about the risk of liver cancer from alcohol consumption. Throat and Mouth Cancer: Participants will view messages about the risk of throat and mouth cancer from alcohol consumption. Colorectal Cancer: Participants will view messages about the risk of colorectal cancer from alcohol consumption. Multiple Cancers: Participants will view messages about the risk of multiple cancers from alcohol consumption. Liver Disease: Participants will view messages about the risk of liver disease from alcohol consumption. Hypertension: Participants will view messages about the risk of hypertension from alcohol consumption. Dementia: Participants will view messages about the risk of dementia from alcohol consumption. Drinking Guidelines: Participants will view messages about guidelines for alcohol consumption. Current Warning: Participants will view the current warning that is required on most alcoholic beverage containers sold in the US. Control: Participants will view neutral messages unrelated to the harms of alcohol consumption. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Marissa Hall, PhD | University of North Carolina at Chapel Hill | 919-445-1310 | mghall@unc.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jul 24, 2025 | Jul 29, 2025 | Prot_SAP_002.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 28, 2024 | Dec 10, 2024 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D000428 | Alcohol Drinking |
| ID | Term |
|---|---|
| D004327 | Drinking Behavior |
| D001519 | Behavior |
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| Throat and Mouth Cancer | Behavioral | Participants will view messages about the risk of throat and mouth cancer from alcohol consumption. |
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| Colorectal Cancer | Behavioral | Participants will view messages about the risk of colorectal cancer from alcohol consumption. |
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| Multiple Cancers | Behavioral | Participants will view messages about the risk of multiple cancers from alcohol consumption. |
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| Liver Disease | Behavioral | Participants will view messages about the risk of liver disease from alcohol consumption. |
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| Hypertension | Behavioral | Participants will view messages about the risk of hypertension from alcohol consumption. |
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| Dementia | Behavioral | Participants will view messages about the risk of dementia from alcohol consumption. |
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| Drinking Guidelines | Behavioral | Participants will view messages about guidelines for alcohol consumption. |
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| Current Warning | Behavioral | Participants will view the current warning that is required on most alcoholic beverage containers sold in the US. |
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| Control | Behavioral | Participants will view neutral messages unrelated to the harms of alcohol consumption. |
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| Assessed during one-time 15-minute online study survey |
| Learning Something New | The study will assess learning something new with 1 item: "Did you learn something new from this message?" Response options will be yes (1) and no (0). Proportion of participants who endorsed learning something new (i.e., answered 1). Survey weighted proportions are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. | Assessed during one-time 15-minute online study survey |
| Participants |
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| Sex/Gender, Customized | Count of Participants | Participants |
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| Race/Ethnicity, Customized | Count of Participants | Participants |
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| Region of Enrollment | Count of Participants | Participants |
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| Secondary | Reminding of Alcohol's Harms | The study will assess reminding of alcohol's harms using 1 item: "How much does this message remind you that drinking alcohol can be harmful?" Response options will range from not at all (1) to a great deal (5). Higher scores indicate greater reminding of alcohol's harms. Survey weighted means are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. | Posted | Mean | Standard Error | score on a scale | Assessed during one-time 15-minute online study survey |
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| Secondary | Learning Something New | The study will assess learning something new with 1 item: "Did you learn something new from this message?" Response options will be yes (1) and no (0). Proportion of participants who endorsed learning something new (i.e., answered 1). Survey weighted proportions are reported to account for NORC AmeriSpeak's sampling design to enable results to be statistically representative of the US population of drinkers age >/=21 who drink alcohol. | Posted | Number | proportion of positive responses | Assessed during one-time 15-minute online study survey |
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| Title | Measurements |
|---|---|
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| Liver cancer |
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| Throat and mouth cancer |
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| Liver disease |
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| Hypertension |
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| Current warning |
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| Guidelines |
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| Control |
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| <0.001 |
| Mean Difference (Final Values) |
| 1.59 |
| 2-Sided |
| Superiority |
| Colorectal cancer vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.54 | 2-Sided | Superiority |
| Liver cancer vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.60 | 2-Sided | Superiority |
| Throat and mouth cancer vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.66 | 2-Sided | Superiority |
| Liver disease vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.52 | 2-Sided | Superiority |
| Hypertension vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.45 | 2-Sided | Superiority |
| Current warning vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 1.52 | 2-Sided | Superiority |
| Guidelines vs. Control | Mixed Models Analysis | <0.001 | Mean Difference (Final Values) | 0.93 | 2-Sided | Superiority |
| Title | Measurements |
|---|---|
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| Liver cancer |
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| Throat and mouth cancer |
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| Liver disease |
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| Hypertension |
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| Current warning |
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| Guidelines |
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| Control |
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| <0.001 |
| Difference in predicted proportions |
| 0.34 |
| 2-Sided |
| Superiority |
| Colorectal cancer vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.40 | 2-Sided | Superiority |
| Liver cancer vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.14 | 2-Sided | Superiority |
| Throat and mouth cancer vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.37 | 2-Sided | Superiority |
| Liver disease vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.11 | 2-Sided | Superiority |
| Hypertension vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.25 | 2-Sided | Superiority |
| Current warning vs. Control | Mixed Models Analysis | 0.02 | Difference in predicted proportions | 0.04 | 2-Sided | Superiority |
| Guidelines vs. Control | Mixed Models Analysis | <0.001 | Difference in predicted proportions | 0.14 | 2-Sided | Superiority |