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This clinical study aims to explore the effects of probiotics on inflammatory and metabolic indicators in patients with type 2 diabetes. By assessing the potential of probiotics to modify these markers, the study seeks to identify an economical and effective strategy for the prevention and treatment of type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Probiotics | Experimental | Participants will receive a probiotic strip (3g/strip) daily alongside their standard clinical treatment for a continuous 12-week period. |
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| Maltodextrin | Placebo Comparator | Participants will take a daily placebo strip (3g/strip) in addition to their regular clinical treatment over a continuous 12-week period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotics | Dietary Supplement | Serum and fecal samples were collected at the beginning and end of the study to evaluate the effects of probiotic consumption on immune markers, metabolites, and gut microbiota before and after administration. |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammatory markers | Blood samples will be collected from patients with type 2 diabetes mellitus (T2DM), centrifuged to obtain serum, and analyzed for tumor necrosis factor-alpha (TNF-α), interleukins 6 (IL-6), 10 (IL-10), and 18 (IL-18), IL-1β, and interferon-gamma (IFN-γ) to assess the impact of probiotics on T2DM patients. | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Kang Liu, Doctor | Contact | 15808432375 | +86 | liukang@nsmc.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanchong Central Hospital | Nanchong | Sichuan | 637000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41971606 | Derived | Zhu S, Qiao Y, He W, Xiao Y, Song G, Liu K, Fang S. Multi-Strain Probiotics BLa80, LRa05, and BBr60 Modulate Inflammation, Bile Acids, and Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial. Food Sci Nutr. 2026 Apr 10;14(4):e71735. doi: 10.1002/fsn3.71735. eCollection 2026 Apr. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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| D004700 | Endocrine System Diseases |
| D019602 |
| Food and Beverages |