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The goal of this pilot and feasibility study is to is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust (KCH).
The main aim is to assess and compare anthropometric measurements of adiposity (weight, Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip ratio (WHR), Neck circumference (NC)), liver fat (hepatic steatosis and fibrosis), cardiometabolic risk factors (dyslipidemia, insulin resistance, hypertension) and neurocognitive risk factors among participants, according to their ethnic background.
Participants will come at KCH for one visit and will have their anthropometric measurements and cardio-metabolic profile assessed. They will also perform questionnaires on lifestyle, socio-economic status and neuro-cognitive health during their visit.
The first objective of this study is to test the feasibility of conducting a cross-sectional study on adiposity and cardiometabolic and neurocognitive risk factors at Kings College Hospital NHS Foundation Trust.
The second objective is to assess and compare anthropometric measurements of adiposity (weight, Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip ratio (WHR), Neck circumference (NC)), liver fat (hepatic steatosis and fibrosis), cardiometabolic risk factors (dyslipidemia, insulin resistance, hypertension) and neurocognitive risk factors among participants, according to their ethnic background.
The third objective is to test the feasibility of assessing cognitive function, in relation to adiposity, by using standardised tests measuring cognitive function (MMSE, MoCA or an adapted version) among ethnic groups of various education levels and literacy, lifestyle and from different cultures. Our objective is also to test the feasibility of using lifestyle questionnaires [Food Frequencies Questionnaires (FFQ) and International Physical Activity Questionnaires -(IPAQ-S)] in various ethnic groups with regard to geographic variation (urban, rural).
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| Measure | Description | Time Frame |
|---|---|---|
| Height | Measured without shoes and reported in centimeters | 1 minute |
| Insulin resistance | random plasma glucose, glycated haemoglobin (HbA1c) using a blood test | 10 minutes |
| Type 2 Diabetes | random plasma glucose, glycated haemoglobin (HbA1c) using a blood test | 10 minutes |
| Hepatic steatosis, and stages of fibrosis | Assessed by a certified physician using transient elastography (TE) measurements using a Fibroscan (Model mini-430). | 10 minutes |
| neurocognitive risk factors | Result below 25 on the Montreal Cognitive Assessment test (MoCA). No minimum results, normal is above or equal to 26. The lower the result is the more the participant is at risk of presenting any form of neuro-cognitive impairment. | 15 minutes |
| Weight | Measured using an automatic scale, without shoes. Reported in kilograms. | 1 minute |
| BMI | Will be calculated from weight and height results and will be presented in kg/m2. | 30 seconds |
| Waist circumference | Will be measured with a tape around the middle point halfway between the top of the hips and the bottom of the ribs, at expiration. Will be reported in centimeters. |
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Inclusion Criteria:
Exclusion Criteria:
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Adult male and female living with obesity (BMI ≥ 30 kg/m2 )
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fannie Lajeunesse-Trempe, MD, Msc | Contact | 14384901454 | fanny.lajeunesse-trempe.1@ulaval.ca | |
| Georgios K. Dimitriadis, MD, PhD | Contact | g.dimitriadis@nhs.net |
| Name | Affiliation | Role |
|---|---|---|
| Georgios K. Dimitriadis, PhD | Kings College Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King's College Hospital NHS Foundation Trust | Active, not recruiting | London | United Kingdom of Great Britain and Northern Ireland | SE5 9RS | United Kingdom |
Data will be shared among different collaborative centers to compare outcomes among different ethnic groups from rural and urban environment of low- middle and high income countries.
1 year
To have collected 10 participants (5 males and 5 females) as per protocol and have agreed on a specific data sharing agreement signed by all parties.
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| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| D009765 | Obesity |
| D002318 | Cardiovascular Diseases |
| D060825 | Cognitive Dysfunction |
| D005234 | Fatty Liver |
| ID | Term |
|---|---|
| D009750 | Nutritional and Metabolic Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| 1 minute |
| Hip circumference | Will be measure with a tape around the widest part of the hips. Will be reported in centimeters. | 1 minute |
| Dyslipidemia | Will be diagnosed from lipid levels reported in a blood test | 10 minutes |
| Neck circumference | Will be measure with a tape around a point just below the larynx (Adam's Apple) and perpendicular to the long axis of the neck. The participant should look straight ahead during measurement, with shoulders down (not hunched). Round the neck measurement up to nearest ½ centimeters. Result will be reported in centimeters. | 1 minutes |
| Waist-to-Hip ratio | Will be derived from waist circumference and hip circumference. | 30 seconds |
| Waist-to-Height ratio | Will be derived from waist circumference and height. | 30 seconds |
| Hypertension (estimated using blood pressure measurement) | blood pressure will consist of 3 systolic blood pressure and diastolic blood pressure measurements | 10minutes |
| King's College Hospital NHS Foundation Trust | Recruiting | London | SE5 9RS | United Kingdom |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |