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| ID | Type | Description | Link |
|---|---|---|---|
| ONZ-2023-0365 | Other Identifier | Ethical committee Ghent University |
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| Name | Class |
|---|---|
| Research Foundation Flanders | OTHER |
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The goal of this observational study is to explore the significance of subject-reported outcomes and clinical parameters in relation to the occurence of prolonged presence of arthrogenic muscle responses (AMR) in anterior cruciate ligament (ACL) reconstructed patients. The main questions it aims to answer are:
1. Is there a link between the long-term occurence of AMR in ACL reconstructed patients and the level of kinesiophobia experienced before or after their ACL surgery? We hypothesize that ACL patients with higher levels of kinesiophobia are more likely to exhibit prolonged AMR as an unconscious reaction to protect their affected knee joint.
2. Is the long-term presence of AMR in ACL reconstructed patients linked to their subjective knee function and stability (at certain time points throughout their recovery)? Our hypothesis is that poorer subjective knee function and stability might be associated with the presence of prolonged arthrogenic muscle responses in ACL reconstructed patients.
3. Is the prolonged presence of AMR in ACL reconstructed patients linked to their pain levels (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with higher pre- and/or postsurgical pain levels may exhibit a higher degree of long-lasting AMR.
4. Is the long-term presence of AMR in ACL reconstructed patients linked to clinical parameters such as swelling, isometric quadriceps and hamstrings strength and knee range of motion (at certain time points throughout their recovery)? Our hypothesis is that ACL patients with poorer outcomes in terms of these clinical parameters may be more likely to exhibit prolonged AMR.
Participants will:
Fill in the following questionnaires 1 week before surgery and at 1 and 3 months after surgery:
Complete a testing protocol 5 months after their surgery, which includes bilateral electromyographical measurements of the hamstrings and quadriceps during jumping tasks and a quadriceps inhibition measurement using the interpolated twitch method to evaluate the presence of prolonged AMR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ACLR-patients | The participants to be studied will have an anterior cruciate ligament injury for which surgical treatment is scheduled. |
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| Measure | Description | Time Frame |
|---|---|---|
| Voluntary quadriceps activation | A torque-based isometric biodex measurement using the interpolated twitch technique. | 5 months post ACL reconstruction |
| Quadriceps and hamstrings activity / cocontraction during jumping tasks | Electromyographical measurement of quadriceps and hamstrings activation during jumping tasks: bilateral countermovement jump, unilateral countermovement jump and unilateral vertical drop jump with a 90° medial turn. The cocontraction will be quantified with cocontraction indices. | 5 months post ACL reconstruction |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps strength | Concentric and isokinetic Biodex measurements of the quadriceps strength | 5 months post ACL reconstruction |
| Hamstrings strength | Concentric and isokinetic Biodex measurements of the quadriceps strength |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged between 18 and 40 who have suffered an ACL rupture and for whom ACL reconstructive surgery is planned at AZ Delta Hospital in Roeselare.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Erik Witvrouw, prof. dr. | Contact | +32 9 332 2609 | erik.witvrouw@ugent.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AZ Delta Hospital (Campus Brugsesteenweg) | Recruiting | Roeselare | West-Vlaanderen | 8800 | Belgium |
All collected IPD that underlie results in a publication will be shared.
The data will become available after publication.
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| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
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| 5 months post ACL reconstruction |
| Patient reported knee function | Questioned using the Knee Injury and Osteoarthritis Outcome Score (KOOS). Scores on the KOOS range from 0-100, with 0 representing the greatest possible problems in terms of knee function and 100 representing no problems. | 5 months post ACL reconstruction |