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The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed.
In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group | Experimental | In test group, after reflection of flap and degranulation, IGF-1 gel with hydroxyapatite will be placed in the defect and sutures will be placed. |
|
| Control group | Active Comparator | In control group, after reflection of flap and degranulation, hydroxyapatite will be placed in the defect and sutures will be placed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IGF-1 Gel | Procedure | After degranulation of the defect, IGF-1 gel mixed with Hydroxyapatite graft will be placed in the defect. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bone Regeneration | Radiovisiography (RVG) will be used to assess bone regeneration achieved post operatively after 3 months and 6 months. | 3 months and 6 months |
| clinical attachment level | Assessment of clinical attachment level using UNC-15 probe at baseline and post operatively at 3 and 6 months. | 3 months and 6 months |
| Probig depth | Assessment of probing depth using UNC-15 probe at baseline and postoperatively at 3 and 6 months. | 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index | Assessment of plaque (PI) - according to Turesky modification of Quigley and Hein Plaque Index, 1970. | 3 months and 6 months |
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Inclusion Criteria:
Systemically healthy male and female patients of age >18 years Intrabony defects - two wall or three wall defects Probing pocket depths (PPD) of >5mm.
Exclusion Criteria:
Medically compromised patients Pregnant women Heavy smokers Patients who underwent radiotherapy or chemotherapy are excluded
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dr R Viswa Chandra, MDS;DNB;PhD | Contact | 8179367147 | viswachandra@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SVS Institute of Dental Sciences, Mahabubnagar | Recruiting | Hyderabad | Telangana | 509002 | India |
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| ID | Term |
|---|---|
| D017886 | Durapatite |
| ID | Term |
|---|---|
| D006882 | Hydroxyapatites |
| D001031 | Apatites |
| D002130 | Calcium Phosphates |
| D010710 | Phosphates |
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| Hydroxyapatite | Procedure | After degranulation of the defect, Hydroxyapatite graft will be placed in the defect. |
|
| D010756 |
| Phosphoric Acids |
| D017976 | Phosphorus Acids |
| D000148 | Acids, Noncarboxylic |
| D000143 | Acids |
| D007287 | Inorganic Chemicals |
| D017610 | Calcium Compounds |
| D008903 | Minerals |
| D017553 | Phosphorus Compounds |