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The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar depression
We will apply stimulatory TMS protocol for participants with Unipolar depression and participants with bipolar depression using MagVenture MagPro R30 stimulator with the Cool-B65 coil
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants with unipolar depression | Experimental | Participants with Unipolar depression will receive 30 sessions of TMS.10 sessions a week for 3 weeks |
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| Participants with bipolar depression | Experimental | Participants with bipolar depression will receive 30 sessions of TMS.10 sessions a week for 3 weeks |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transmagnetic stimulation | Device | Stimulatory TMS protocol using MagVenture MagPro R30 stimulator with the Cool-B65 coil |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of severity of manic symptoms before and after treatment | We will use Young Mania Rating Scale._Young Mania Rating Scale:assess severity of manic symptoms, clinician rated,<=12(remission)13_19(minimal symptoms)20_25(mild mania)26_37(moderate mania)38_60 severe mania | One year for completion of the study |
| Comparison of the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis. | We will use Clinical Global Impression Severity Scale._Clinical Global Impression Severity Scale:rate the severity of the patient's illness at the time of assessment relative to the clinician's past experience with patients who have the same diagnosis,1 normal not at all ill,2 borderline mentally ill,3 mildly ill,4 moderately ill,5 markedly ill,6 severely ill,7 extremely ill | One year for completion of the study |
| Comparison of severity and impact of insomnia before and after treatment | We will use Insomnia Severity Index scale._Insomnia Severity Index:assess the nature, severity and impact of insomnia,0_7(absence insomnia) 8_14(subthreshold insomnia)15_21(moderate insomnia)22_28(severe insomnia) | One year for completion of the study |
| Comparison of depressive symptoms before and after treatment | We will use Hamilton Depression Rating Scale._Hamilton Depression Rating Scale:assess the severity of depressive symptoms, clinician rated,0_7(normal range)8_16(mild severity)17_23(moderate severity)>23(severe depression) | One year for completion of the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shaimaa E. Mohamed | Contact | Egypt 01014947026 | shaimaa_eldesokey151990@yahoo.com | |
| Warda F. Aboelez | Contact | 01018186408 |
| Name | Affiliation | Role |
|---|---|---|
| Hala A. El-boraie | Professor | Study Chair |
| Ibrahim H. Rashed | Assistant professor | Study Director |
| Hassan M. Sonbol |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University | Al Mansurah | 35516 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33224435 | Background | Chang J, Chu Y, Ren Y, Li C, Wang Y, Chu XP. Maintenance treatment of transcranial magnetic stimulation (TMS) for treatment-resistant depression patients responding to acute TMS treatment. Int J Physiol Pathophysiol Pharmacol. 2020 Oct 15;12(5):128-133. eCollection 2020. |
| Label | URL |
|---|---|
| PMC 7675193 | View source |
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| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| ID | Term |
|---|---|
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| TMS | Device | Stimulatory TMS protocol using MagVenture MagPro R30 stimulator with the Cool-B65 coil |
|
| Lecturer |
| Study Director |