Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression

Accelerated Intermittent Theta Burst Stimulation in Unipolar Versus Bipolar Depression

The goal of this interventional study is to learn if accelerated Intermittent Theta Burst Stimulation can improve symptoms of 30 participants with Unipolar depression in higher manner than symptoms of 30 participants with bipolar depression

We will apply stimulatory TMS protocol for participants with Unipolar depression and participants with bipolar depression using MagVenture MagPro R30 stimulator with the Cool-B65 coil

Inclusion Criteria:

• Age:18_65 years
• Sex:male and female
• Patients with Unipolar depression and bipolar depression diagnosis confirmed by SCID according to DSM5
• No pharmacological change in the last 4 weeks before the beginning of the stimulantion cycle
• Pharmacological resistance

Exclusion Criteria:

• Patients complaining of psychosis.Substance Use Disorder.current suicidal ideation.major medical and neurological disorder
• Patients complaining of epilepsy
• pregnancy and breastfeeding
• peacemaker spinal or bladder stimulator
• History of skull surgery and trauma
• presence of metallic foreign body