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It is well established that rehydration with a carbohydrate-electrolyte solution is more effective in comparison to plain water. This is primarily based on the sodium-glucose co transporter, based on which the world health organization has based its oral rehydration solution recommendations. Also, rehydration with a solution that includes sodium and glucose plasma osmolality should not drop as much as it happens during rehydration with water. As a result, we should have higher fluid intake due to higher thirst perception and lower urinary output due to higher levels of vasopressin.
The present study aims to examine the effectiveness of a electrolyte-glucose drink on rehydration following exercise-induced dehydration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Water | Placebo Comparator | Rehydration with low mineral content bottle water |
|
| Carbohydrate Electrolyte solution | Experimental | Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV |
|
| Low Sugar electrolyte solution | Experimental | 10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plain Water | Other | Plain water without calories, sweetener, or electolytes |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Total fluid intake | Total amount of fluid ingested | 4 hours of rehydration |
| Net fluid balance | amount of water retained during the rehydration period | at 4 hours of the rehydration period |
| Net fluid balance | amount of water retained during the rehydration period | at 3 hours of the rehydration period |
| Rate of absorption | The rate of Deuterium appearance in the blood during 30 minutes of rehydration | during the first 30 minutes of rehydration |
| Rate of absorption | The rate of Deuterium appearance in the blood during 60 minutes of rehydration | during the first 60 minutes of rehydration |
| Rate of absorption | The rate of Deuterium appearance in the blood during 120 minutes of rehydration | during the first 120 minutes of rehydration |
| Rate of absorption | The rate of Deuterium appearance in the blood during 180 minutes of rehydration | during the first 180 minutes of rehydration |
| Rate of absorption | The rate of Deuterium appearance in the blood during 240 minutes of rehydration |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma copeptin | Plasam Copeptin during rehydration | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Plasma volume | percent of plasma volume recovery during the rehydration |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Interdisciplinary Science and Technology Building 8 | Phoenix | Arizona | 85004 | United States |
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| ID | Term |
|---|---|
| D003681 | Dehydration |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D010335 | Pathologic Processes |
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non labeled bottles
| Liquid IV Hydration Multiplier |
| Other |
Drink with 22 grams of carbohydrate, 1020 milligrams of sodium, and 760 milligrams of potassium per liter. Hydration multiplier liquid IV |
|
| Liquid IV Sugar Free | Other | 10 grams of carbohydrate, 1060 milligrams of sodium, and 760 milligrams of potassium per liter. Sugar free Liquid IV |
|
| during the first 240 minutes of rehydration |
| Cumulative urine output | Total amount of urine output during rehydration | during the first 3 hours of rehydration |
| Cumulative urine output | Total amount of urine output during rehydration | during the first 4 hours of rehydration |
| at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Free water Clearance | Free water clearance calculated based on plasma and urine osmolality | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Free Osmotic Clearance | Free Osmotic clearance calculated based on plasma and urine osmolality | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Thirst | Thirst estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Stomach fullness | Stomach fullness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| Taste Likeness | Taste Likeness estimated with a visual analog scale from 0-125 millimeters with higher value indicating greater perception | at 30 minutes, 1 hour, 2 hours, 3 hours and 4 hours of the rehydration period |
| D013568 | Pathological Conditions, Signs and Symptoms |