Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study is a multicenter, non-interventional, retrospective, medical chart review of locally advanced or metastatic (la/m) Urothelial Cancer UC participants who were prescribed avelumab as first line maintenance therapy after a platinum-based chemotherapy. This study aims to understand the index date (i.e., at the initiation of avelumab maintenance therapy) demographics and clinical characteristics of participants with locally advanced/metastatic Urothelial Carcinoma in Japan, and to describe their treatment patterns and outcomes.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Urothelial Carcinoma Cohort | This is a single cohort study enrolling Participants with Urothelial Carcinoma (UC), who are prescribed treatment with avelumab as first line maintenance therapy after a platinum-based chemotherapy (PBCT). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Avelumab | Drug | This is an observational study, participants who received avelumab as first line maintenance therapy after a PBCT. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Baseline clinical and demographic characteristics | To describe the baseline clinical and demographic characteristics of participants. | Baseline |
| Characteristics of the first line PBCT just prior to avelumab maintenance | Up to 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Overall Survival (OS) | Up to 3 months | |
| Progression-Free Survival (PFS) | Up to 3 months | |
| Time to Treatment Failure (TTF) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Participants with locally advanced/metastatic Urothelial Carcinoma
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Medical Responsible | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hirosaki University Hospital | Hirosaki | Aomori | 036-8563 | Japan | ||
| Ehime University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41888732 | Derived | Endo Y, Kitamura H, Shirotake S, Ikeda M, Yonemori K, Kawamura N, Fujihara A, Abe T, Shimizu F, Fujimoto K, Nakagawa T, Hatakeyama S, Nishihara K, Ikarashi D, Masumori N, Naito S, Fujita K, Hara T, Miura N, Negishi T, Yatsuda J, Kobayashi M, Taoka R, Furukawa J, Shono M, Kobayashi T, Kikuchi E. Avelumab maintenance therapy for advanced urothelial carcinoma: subgroup analyses by characteristics of first-line platinum-based chemotherapy from a real-world chart review study in Japan (JAVEMACS). BMC Cancer. 2026 Mar 26;26(1):575. doi: 10.1186/s12885-026-15781-1. |
| Label | URL |
|---|---|
| Trial Awareness and Transparency Website | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Up to 3 months |
| Time to Next Treatment (TTNT) | Up to 3 months |
| Objective Response Rate (ORR) | Up to 3 months |
| Tōon |
| Ehime |
| 791-0295 |
| Japan |
| Kurume University Hospital | Kurume | Fukuoka | 830-0011 | Japan |
| Hokkaido University Hospital | Sapporo | Hokkaido | 060-8648 | Japan |
| Sapporo Medical University Hospital | Sapporo | Hokkaido | 060-8648 | Japan |
| Kobe University Hospital | Kobe | Hyōgo | 650-0017 | Japan |
| Iwate Medical University Hospital | Shiwa-gun | Iwate | 028-3695 | Japan |
| Kagawa University Hospital | Kita-gun | Kagawa-ken | 761-0793 | Japan |
| St. Marianna University Hospital | Kawasaki | Kanagawa | 216-8511 | Japan |
| Kitasato University Hospital | Sagamihara | Kanagawa | 252-0374 | Japan |
| Nara Medical University Hospital | Kashihara | Nara | 634-8522 | Japan |
| Kindai University Hospital | Sayama | Osaka | 589-8511 | Japan |
| Saitama Medical University International Medical Center | Hidaka | Saitama | 350-1298 | Japan |
| Juntendo University Hospital | Bunkyō City | Tokya | 113-0033 | Japan |
| Nippon Medical School Hospital | Bunkyo-ku | Tokyo | 113-8603 | Japan |
| National Cancer Center Hospital | Chuo-ku | Tokyo | 104-0045 | Japan |
| Teikyo University Hospital | Itabashi-ku | Tokyo | 173-8606 | Japan |
| Akita University Hospital | Akita | 010-0041 | Japan |
| Kyushu Cancer Center | Fukuoka | 811-1347 | Japan |
| Kumamoto University Hospital | Kumamoto | 860-8556 | Japan |
| University Hospital Kyoto Prefectural University of Medicine | Kyoto | 602-8566 | Japan |
| Kyoto University Hospital | Kyoto | 606-8507 | Japan |
| Osaka International Cancer Institute | Osaka | 540-0008 | Japan |
| Tokushima University Hospital | Tokushima | 770-0042 | Japan |
| Toyama University Hospital | Toyama | 930-0194 | Japan |
| Yamagata University Hospital | Yamagata | 9902331 | Japan |
| Medical Information Location Map - Med Info Contacts | View source |
| ID | Term |
|---|---|
| D002295 | Carcinoma, Transitional Cell |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
Not provided
Not provided
| ID | Term |
|---|---|
| C000609138 | avelumab |
Not provided
Not provided
Not provided