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The present study will aim to evaluate:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| skin biopsy from vitiligo lesion in vitiligo patient | Active Comparator | punch biopsy 5mm from vitiligo patch in vitiligo patient |
|
| skin biopsy from normal skin in vitiligo patient | Active Comparator | punch biopsy 5mm from normal skin patch in vitiligo patient |
|
| skin biopsy from normal skin in normal person | Active Comparator | punch biopsy 5mm from normal skin patch in normal person |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Punch Biopsy 5mm | Device | Disinfect the skin, inject local anesthesia ,insert the punch and extract the biopsy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of Autophagy Related genes in Vitiligo patients | Assess Autophagy Related genes levels in skin biopsy of vitiligo patient | 2 months |
| Assessment of Hypoxia Inducible Factor in Vitiligo patients | Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rania H Metwally, Resident | Contact | 01018845428 | rania_hassan_post@med.sohag.edu.eg | |
| Reham E El-Sharkawy, Professor | Contact | 01006809003 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag University hospitals | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32503939 | Background | Agarwal S, Ganesh S. Perinuclear mitochondrial clustering, increased ROS levels, and HIF1 are required for the activation of HSF1 by heat stress. J Cell Sci. 2020 Jul 9;133(13):jcs245589. doi: 10.1242/jcs.245589. | |
| 36553654 | Background | Artika IM, Dewi YP, Nainggolan IM, Siregar JE, Antonjaya U. Real-Time Polymerase Chain Reaction: Current Techniques, Applications, and Role in COVID-19 Diagnosis. Genes (Basel). 2022 Dec 16;13(12):2387. doi: 10.3390/genes13122387. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 2, 2026 | |
| Reset | Jun 26, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 2, 2026 | Jun 26, 2026 |
| ID | Term |
|---|---|
| D014820 | Vitiligo |
| ID | Term |
|---|---|
| D017496 | Hypopigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| 33767135 | Background | Bastonini E, Kovacs D, Raffa S, Delle Macchie M, Pacifico A, Iacovelli P, Torrisi MR, Picardo M. A protective role for autophagy in vitiligo. Cell Death Dis. 2021 Mar 25;12(4):318. doi: 10.1038/s41419-021-03592-0. |
| 22417114 | Background | Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, Silva de Castro C, Lee AY, Parsad D, van Geel N, Le Poole IC, Oiso N, Benzekri L, Spritz R, Gauthier Y, Hann SK, Picardo M, Taieb A; Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012 May;25(3):E1-13. doi: 10.1111/j.1755-148X.2012.00997.x. |