Patients with retinal vein obstruction and diabetic retinopathy

Cataract surgery and vitrectomy patients

As an important part of systems biology, metabolomics mainly detects various metabolites in the sample. Different from nucleic acids, proteins and other biological macromolecules, the relative molecular weight of these metabolites is small, generally within 1000Da, such as amino acids, carboxylic acids, carbohydrates, alcohols, amines, lipids and other special substances. Through qualitative and quantitative analysis of all endogenous low molecular weight metabolites before and after pathophysiology or gene modification stimulation, metabolomics reveals the essential characteristics of life activities and metabolism of the body, and provides guidance for exploring the pathogenesis, early diagnosis, treatment and prognosis of diseases.

1. Surface markers and key molecules related to the study of diseases were screened out, and a biomarker model for assessing disease prognosis was established.
2. Candidate differential molecules were screened through a training cohort, a Cox regression model was constructed, and the prognostic value of the model was verified in the test cohort.