Analysis of Biomarkers From Patients With Chorioretinal Diseases

Analysis of Biomarkers From Patients With Chorioretinal Diseases

This study was conducted to investigate the levels of ocular biomarkers from the patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

This prospective, case-control study included 50 patients(50eyes) with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 patient with nondiabetic retinopathy or cataract. Ocular fluids and blood samples were taken before injection of anti-vascular endothelial growth factor agent or pars plana vitrectomy for other retinal disease. Ocular biomarkers were analyzed.

Inclusion Criteria:

• age over 20 years
• patients requiring ophthalmologic treatments for different degrees of decreasing of visual acuity.
• patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.
• control patients asking cataract surgery or vitrectomy for posterior segment nonproliferative disorders.

Exclusion Criteria:

• under the age of 20 years
• patients that received any anti-vascular endothelial growth factor agent for proliferative disease before taking sample of aqueous humor
• patients that did not signed the informed consent of the trial
• patients with intraocular inflammations or infections that requiring any pharmaceutical agent
• patients with recent ocular trauma