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This was a double-blind, randomized, placebo-controlled clinical study aiming to assess the effects of supplementation with CoQ10 phytosome on physical performance in older adults with self-reported statin-associated asthenia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coenzyme Q10 | Active Comparator | 2 pills of 150 mg CoQ10 phytosome (i.e. 300 mg CoQ10 phytosome per day) |
|
| Placebo | Placebo Comparator | 2 pills of placebo per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coenzyme Q10 | Dietary Supplement | 2 pills/day of 150 mg CoQ10 phytosome (i.e. 300 mg CoQ10 phytosome per day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effect on handgrip strength | We evaluated the effect on handgrip strength after 8 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. A hand-held dynamometer was used to assess handgrip strength. Measurements were assessed according to the International standard protocols, and obtained after participants performed one familiarization trial with both hands. | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Effect on handgrip strength | We evaluated the effect on handgrip strength after 4 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. A hand-held dynamometer was used to assess handgrip strength. Measurements were assessed according to the International standard protocols, and obtained after participants performed one familiarization trial with both hands. |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Claudio Borghi, MD, PhD | University of Bologna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bologna | Bologna | BO | 40138 | Italy |
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| ID | Term |
|---|---|
| D006937 | Hypercholesterolemia |
| D001247 | Asthenia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
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| Placebo | Other | 2 pills/day |
|
| 4 weeks |
| Effect on statin-associated asthenia | We evaluated the effect on asthenia after 4 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. Asthenia was assessed on a 10-point visual analogue scale (VAS), considering 0= absence of asthenia and 10= extreme asthenia. | 4 weeks |
| Effect on statin-associated asthenia | We evaluated the effect on asthenia after 8 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. Asthenia was assessed on a 10-point visual analogue scale (VAS), considering 0= absence of asthenia and 10= extreme asthenia. | 8 weeks |
| Effect on 1-min sit-to-stand repetitions | We evaluated the effect on 1-min sit-to-stand repetitions after 4 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. | 4 weeks |
| Effect on 1-min sit-to-stand repetitions | We evaluated the effect on 1-min sit-to-stand repetitions after 8 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. | 8 weeks |
| Effect on 2-minute step test | We evaluated the effect on 2-minute step test after 4 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. | 4 weeks |
| Effect on 2-minute step test | We evaluated the effect on 2-minute step test after 8 weeks of dietary supplementation with CoQ10 phytosome compared to either baseline and placebo. | 8 weeks |
| D009750 |
| Nutritional and Metabolic Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |