CoQ10 in Statin-associated Asthenia

Effect of Coenzyme Q10 on Physical Performance in Elderly Patients With Statin-associated Asthenia: a Double-blind, Randomized, Placebo-controlled Clinical Trial

This was a double-blind, randomized, placebo-controlled clinical study aiming to assess the effects of supplementation with CoQ10 phytosome on physical performance in older adults with self-reported statin-associated asthenia.

Inclusion criteria:

• 65-80 years of age
• treatment for >6 months with statin monotherapy (i.e. enrolled individuals were asked to be on the same statin at the same dosage for >6 months)
• statin-associated asthenia for >3 months

Exclusion criteria:

• serious or disabling diseases (e.g. severe organ failure, malignancy or dementia)
• orthopedic disorders, myopathies and any other acute or chronic disease that could significantly affect the individual's perception of asthenia
• obesity (body mass index (BMI)> 30 Kg/m2)
• known gastrointestinal disorders potentially affecting the absorption of CoQ10