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| ID | Type | Description | Link |
|---|---|---|---|
| 1K99AR085752-01 | U.S. NIH Grant/Contract | View source | |
| A536130 | Other Identifier | UW Madison | |
| SMPH/ORTHO&REHAB/PHYS THER | Other Identifier | UW Madison | |
| Protocol Version 10/1/2025 | Other Identifier | UW Madison |
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| Name | Class |
|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | NIH |
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The goal of this observational study is to understand how diffusion tensor imaging (DTI) relates to other traditional measures and knee function. The main question it aims to answer is:
Will regions of known patellar tendon pathology present with smaller DTI scalar parameters, shorter fiber length, and lower fiber density compared to the contralateral tendon and healthy regions in the ipsilateral tendon.
Participants will:
Patellar tendon injuries are commonly accompanied by macrostructural alterations captured on common imaging modalities, and the extent of these alterations correlate to knee joint function. Evidence for using tendon macrostructure for diagnosis and prognosis of tendon injuries is not as clear, suggesting that these imaging modalities are not providing a complete picture of the alterations. Diffusion tensor imaging (DTI) tractography can quantify tendon microstructures that underlie the alterations in pathological tendons and shows promising results in healthy tendons. This study is the first step in evaluating whether tendon microstructure captured using DTI technology can be applied as a biomarker to optimize treatment for patellar tendon injuries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bone-patellar tendon-bone (BPTB) | This group will have patellar injury confirmed through self-reported surgical history and evidence of ipsilateral BPTB graft harvest on ultrasound. |
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| Patellar tendinopathy group | This group will have patellar tendinopathy confirmed based on International Scientific Tendinopathy Symposium Consensus on Clinical Terminology (ICON) statement, which defines patellar tendinopathy as "persistent patellar tendon pain and loss of function related to mechanical loading." Ultrasound diagnosis must confirm alteration of tendon macrostructure. |
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| Healthy knees | Control group of participants with healthy knees |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Device | MRI using DTI technology |
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| Measure | Description | Time Frame |
|---|---|---|
| Compare scalar parameters of known patellar tendon pathology to the contralateral tendon | DTI parameters will be obtained by built-in diffusion-weighted sequences on the GE MRI machine. Regions of interest will be selected using clinical scans, and region specific DTI parameters will be compared between regions and over the repeat test sessions | Up to 2 weeks |
| Compare DTI scalar parameters of known patellar tendon pathology to the healthy regions in the ipsilateral tendon | DTI parameters will be obtained by built-in diffusion-weighted sequences on the GE MRI machine. Regions of interest will be selected using clinical scans, and region specific DTI parameters will be compared between regions and over the repeat test sessions | Up to 2 weeks |
| Rank patellar tendon loads during exercise | Patellar tendon loads will be obtained by tensiometer measurements during common exercises for patellar tendon rehabilitation while subject wears NMES sensors. Patellar tendon loads will be compared between regions and over the repeat test sessions. | Up to 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Cases: Adults 18 years or older with a diagnosis of patellar tendinopathy, or with a history of anterior cruciate ligament (ACL) reconstruction using bone-patellar tendon-bone autograft.
Controls: Adults 18 years or older without a diagnosis of patellar tendinopathy or history of ACL reconstruction using bone-patellar tendon-bone autograft
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| Name | Affiliation | Role |
|---|---|---|
| Bryan Heiderscheit, PT, PhD | University of Wisconsin, Madison | Principal Investigator |
| Daniel Cobian, DPT, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Wisconsin - Madison | Madison | Wisconsin | 53705 | United States |
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| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Ultrasound (US) | Device | Standard US |
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| Neuromuscular electric stimulation (NMES) | Device | Standard NMES |
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