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| Name | Class |
|---|---|
| The Danish Medical Research Council | OTHER |
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The purpose of the study is to test the hypothesis that stimulation of the synthesis of new structural tendon proteins combined with training improve the tendon structure in patients with chronic knee tendon pain.
Randomized controlled intervention study: 12 weeks intervention period with training and injections of saline or Insulin-Like growth factor I. One year follow-up
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Insulin-like growth factor I | Active Comparator | 3 injection (1 mg), once a week the first 3 weeks of the 12 weeks of intervention |
|
| Placebo injections | Placebo Comparator | 3 Injections of saline into the patellar tendon 3 times during the first 3 weeks of the 12 weeks interventions period |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insulin-like growth factor I | Drug |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Tendon structure | After 12 weeks intervention (tendon biopsy) |
| Measure | Description | Time Frame |
|---|---|---|
| Tendon Pain | questionnaire | 1 year (before and after 12 weeks intervention and 1 year after intervention start) |
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Inclusion Criteria:
Exclusion Criteria: injection
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| Name | Affiliation | Role |
|---|---|---|
| Michael Kjaer, Professor | Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, 2400 Copenhagen, Denmark | Principal Investigator |
| Mette Hansen, PhD | Section of Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000 Aarhus C, Denmark | Principal Investigator |
| Jens Olesen, PhD | Institute of Sports Medicine, Copenhagen, Bispebjerg Hospital, 2400 Copenahagen, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Sports Medicine, Copenhagen | Copenhagen | 2400 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34138667 | Derived | Olesen JL, Hansen M, Turtumoygard IF, Hoffner R, Schjerling P, Christensen J, Mendias CL, Magnusson PS, Kjaer M. No Treatment Benefits of Local Administration of Insulin-like Growth Factor-1 in Addition to Heavy Slow Resistance Training in Tendinopathic Human Patellar Tendons: A Randomized, Double-Blind, Placebo-Controlled Trial With 1-Year Follow-up. Am J Sports Med. 2021 Jul;49(9):2361-2370. doi: 10.1177/03635465211021056. Epub 2021 Jun 17. |
| Label | URL |
|---|---|
| Study location | View source |
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| ID | Term |
|---|---|
| D052256 | Tendinopathy |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D013708 | Tendon Injuries |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D007334 | Insulin-Like Growth Factor I |
| ID | Term |
|---|---|
| D013002 | Somatomedins |
| D000096764 | Insulin-Like Peptides |
| D036341 | Intercellular Signaling Peptides and Proteins |
| D010455 | Peptides |
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|
|
| D000602 | Amino Acids, Peptides, and Proteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D001685 | Biological Factors |