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| ID | Type | Description | Link |
|---|---|---|---|
| A536000 | Other Identifier | UW Madison | |
| SMPH/OPHTHAL&VIS SCI/GEN | Other Identifier | UW Madison | |
| Protocol Version 3/11/25 | Other Identifier | UW Madison |
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The goal of this research study is to compare two ultrawide field cameras to the gold standard imaging system to evaluate the back of the eye. The main question it aims to answer is the same results and information can be acquired from all of the cameras for evaluating and monitoring inherited retinal diseases (IRDs).
Participants will:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fundus autofluorescence (FAF) imaging | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Spectralis FAF imaging | Device | Spectralis is a scanning laser ophthalmoscope which uses a blue light excitation wavelength of 488nm and a 500nm barrier filter to produce FAF images. Spectralis images 20-55 degrees of the retina. |
| Measure | Description | Time Frame |
|---|---|---|
| Compare FAF retinal patterns by Clarus and standard Spectralis FAF imaging | Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices. | Up to 2 hours |
| Compare FAF retinal patterns by Optos and standard Spectralis FAF imaging | Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices. | Up to 2 hours |
| Compare FAF retinal patterns by Clarus and Optos FAF imaging | Graders will independently measure area of FAF retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices. | Up to 2 hours |
| Compare Spectralis FAF imaging to Spectralis OCT imaging | In participants with clearly defined macular FAF retinal pattern changes, graders will independently measure area of retinal patterns from images of each device. The measurements (in mm²) will be compared between the two devices. | Up to 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of FAF retinal pattern changes beyond the standard 30 degress in Clarus and Optos ultrawide field images | The presence of FAF retinal pattern changes outside field 2 will be documented from the two ultrawide field imaging devices | Up to 2 hours |
| Prevalence of other autofluorescence abnormalities unique to the IRD across all imaging |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angie Adler | Contact | 608-265-7557 | amadler1@wisc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Kimberly Stepien, MD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology and Visual Sciences | Recruiting | Madison | Wisconsin | 53705 | United States |
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| ID | Term |
|---|---|
| D012164 | Retinal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| Optos imaging | Device | Optos is an ultrawide field imaging platform which images up to 200 degrees of the retina. It uses both a green-light excitation wavelength of 532nm and a red-light excitation wavelength of 633nm with an emission filter of greater than 540nm to produce FAF images. |
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| Clarus imaging | Device | Clarus 700 is an ultrawide field imaging system with similar retinal coverage to that of Optos. It uses Broad Line Fundus Imaging to produce blue FAF images at excitation wavelengths of 435-500nm and green FAF images at wavelengths of 500-585nm |
|
The presence of abnormal autofluorescence outside field 2 will be documented from the two ultrawide field imaging devices |
| Up to 2 hours |