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| Name | Class |
|---|---|
| Peking University Third Hospital | OTHER |
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To determine the relationship between the effects of different frequencies and duration of Tai Chi Chuan in dose parameters to improve cognitive function in elderly persons with mild cognitive impairment.
Mild cognitive impairment (MCI) is regarded as a prodrome to dementia and affects 16% to 20% of people aged older than 65 years. Tai Chi Chuan is an increasingly popular multi-modal physical and mental exercise. Studies have shown that Tai Chi Chuan can effectively improve the cognitive function of elderly persons with MCI. However, the relationship between the effects of different frequencies and duration of Tai Chi Chuan to improve the cognitive function of elderly persons with MCI is not yet clear. The purpose of this study is to determine the optimal frequency and duration of Tai Chi Chuan. The investigators will conduct a single-blind, randomized controlled trial in 350 persons who meet the presence of MCI without dementia. Persons will be randomly assigned to either the Tai Chi Chuan intervention group once or twice a week for 12 or 24 weeks, or the health education control group once every four weeks for 24 weeks. All groups will be followed for 52 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi Chuan Group1 | Experimental | 12 weeks of Tai Chi Chuan, 3x/week |
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| Tai Chi Chuan Group2 | Experimental | 12 weeks of Tai Chi Chuan, 5x/week |
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| Tai Chi Chuan Group3 | Experimental | 24 weeks of Tai Chi Chuan, 3x/week |
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| Tai Chi Chuan Group4 | Experimental | 24 weeks of Tai Chi Chuan, 5x/week |
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| Control | Sham Comparator | Participants would take standard health education 0.5hour/ session, 2 sessions/month for 6 months. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lower frequency, shorter period of Tai Chi Chuan | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3 sessions/week for 12 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment | Global cognition | 12 weeks, 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment | Global cognition | 52 weeks |
| Wechsler Memory Scale | Memory function | 12 weeks, 24 weeks and 52 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| The Pittsburgh Sleep Quality Index (PSQI) | Sleep quality | 12 weeks, 24 weeks and 52 weeks |
| 12-Item Short Form Health Survey | General health | 12 weeks, 24 weeks and 52 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Higher frequency, shorter period of Tai Chi Chuan | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 12 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months. |
|
| Lower frequency, longer period of Tai Chi Chuan | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3 sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months. |
|
| Higher frequency, longer period of Tai Chi Chuan | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard health education 0.5 hour/session, 2 sessions/month for 6 months. |
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| Standard Health Education | Behavioral | Participants would take standard health education 0.5 hour/ session, 2 sessions/month for 6 months. |
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| Digit Symbol Substitution Test | Attention | 12 weeks, 24 weeks and 52 weeks |
| Trial Making Test part B | Executive Function | 12 weeks, 24 weeks and 52 weeks |
| Stroop Color Word Test | Processing Speed | 12 weeks, 24 weeks and 52 weeks |
| Boston Naming Test | Verbal fluency | 12 weeks, 24 weeks and 52 weeks |
| Rey-Osterrieth Complex Graphics Test | Visuo-spatial ability | 12 weeks, 24 weeks and 52 weeks |
| Rey Auditory Verbal Learning Test | Episodic memory | 12 weeks, 24 weeks and 52 weeks |
| Blood glucose metabolism index | fasting blood glucose | 12 weeks, 24 weeks and 52 weeks |
| Blood lipid metabolism index | total cholesterol (TC); total triglyceride (TG); low density lipoprotein (LDL);high density lipoprotein (HDL) | 12 weeks, 24 weeks and 52 weeks |
| functional Magnetic Resonance Imaging | functional Magnetic Resonance Imaging | 12 weeks or 24 weeks [post-intervention] |
| Electroencephalogram | The power spectrum density of the brain in a relaxed state is measured using a resting-state electroencephalogram (EEG) for the delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), beta (13-30 Hz), and gamma (30-100 Hz) bands. | 12 weeks or 24 weeks [post-intervention] |
| Heart rate variability | Cardiac autonomic modulations | 12 weeks or 24 weeks [post-intervention] |
| Gut microflora | 16S rRNA amplification sequencing was used to detect intestinal microbiota. | 12 weeks, 24 weeks and 52 weeks |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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