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| Name | Class |
|---|---|
| Peking University Third Hospital | OTHER |
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To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.
Taking MCI as a potential gateway, early intervention to delay the occurrence of dementia has become an important consensus in this field. Exercise is an important means to improve cognitive function in MCI, but the effect of exercise is influenced by the dosage. Tai Chi Chuan, is a moderate intensity aerobic exercise. Previous studies by our team and others had confirmed its effect on cognitive function in MCI. However, the dose parameters of Tai Chi Chuan exercise varied in these studies, and the dose-response relationship is still unclear. The purpose of this study is to explore the dose-response relationship between different volume of Tai Chi Chuan exercise and cognitive function（global cognition and cognition of subdomains）in elderly MCI patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi Chuan Group1 | Experimental | Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks. |
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| Tai Chi Chuan Group2 | Experimental | Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks. |
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| Tai Chi Chuan Group3 | Experimental | Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks. |
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| Tai Chi Chuan Group4 | Experimental | Tai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks. |
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| Tai Chi Chuan Group5 | Experimental | Tai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks. |
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| Tai Chi Chuan Group6 | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi Chuan （dose 1） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment | Global cognition | 8 weeks, 16 weeks, 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment | Global cognition | 52 weeks |
| Wechsler Memory Scale | Memory function | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose metabolism index | fasting blood glucose | 8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks |
| Blood lipid metabolism index | total cholesterol (TC), total triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) |
Inclusion Criteria:
Exclusion Criteria:
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Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks.
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| Tai Chi Chuan Group7 | Experimental | Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks. |
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| Tai Chi Chuan Group8 | Experimental | Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks. |
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| Tai Chi Chuan Group9 | Experimental | Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks. |
|
| Tai Chi Chuan （dose 2） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
|
| Tai Chi Chuan （dose 3） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 30 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
|
| Tai Chi Chuan （dose 4） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
|
| Tai Chi Chuan （dose 5） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
|
| Tai Chi Chuan （dose 6） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 60 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
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| Tai Chi Chuan （dose 7） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
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| Tai Chi Chuan （dose 8） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
|
| Tai Chi Chuan （dose 9） | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks. There were 10 minutes warm-up, 90 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. |
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| Digital Symbol test | Attention | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Trial Making Test part B | Executive function | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Stroop color word test | Processing speed | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Boston naming test | Verbal fluency | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Rey-Osterrieth complex graphics test | Rey-Osterrieth complex graphics test | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| Rey Auditory Verbal Learning Test | Episodic memory | 8 weeks[the duration of intervention arm greater than or equal 8 weeks], 16 weeks [the duration of intervention arm greater than or equal 16 weeks], 24 weeks [the duration of intervention arm is 24 weeks] and 52 weeks |
| 8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks |
| Functional Magnetic Resonance Imaging | Functional Magnetic Resonance Imaging | 8 weeks or 16 weeks or 24 weeks [post-intervention] |
| Electroencephalogram |
| 8 weeks or 16 weeks or 24 weeks [post-intervention] |
| Heart rate variability | cardiac autonomic modulations | 8 weeks or 16 weeks or 24 weeks [post-intervention] |
| Gut microflora | 16S rRNA amplification sequencing will be used to detect intestinal microbiota. Stool sample from each sub center will be stored within 1 h of collection at - 80 °C freezer. Subsequently, the fecal samples will be stored in dry ice and transported in batches to the laboratory within 8 hours, followed by storage in - 80 °C freezer. | 8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks |
| Sleep Quality | The Pittsburgh Sleep Quality Index will be used to evaluate sleep quality, with a total score of 0-21. The higher the score, the poorer the sleep quality. | 8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks |
| General health | 12-Item Short Form Health Survey will be used to evaluate general health. the higher the total score, the better the individual's health status. | 8 weeks or 16 weeks or 24 weeks [post-intervention] and 52weeks |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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