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This study is a cross-sectional study to explore the endocrine metabolism and inflammatory characteristics of the offspring of mothers with PCOS hyperandrogenism, in order to provide a theoretical basis for finding the cause of PCOS.
This study randomly selected 20 women with PCOS and hyperandrogenism who gave birth to a singleton at term at Guangdong Maternal and Child Health Hospital from May 2023 to March 2024, and set them as the HA group. In addition, 22 healthy women were randomly selected as controls. group, the fasting blood glucose (FPG) level of the newborn's peripheral blood and the androgen, fasting insulin and inflammatory factor levels of the newborn's umbilical cord blood were collected respectively.
Among them, the detection indicators of newborn umbilical cord blood include testosterone (T), androstenedione (AND), dehydroepiandrosterone sulfate (DHEA-S), sex hormone binding globulin (SHBG), free androgen index (FAI), Fasting insulin (FINS), white blood cell count (WBC), neutrophil count (NEUT), high-sensitivity C-reactive protein (hs-CRP), and interleukin (IL)-6.
All collected data were statistically analyzed to compare the differences in levels of androgens, fasting insulin, and inflammatory factors in the umbilical cord blood of newborns in the HA group and the control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HA Group | Maternal hyperandrogenism of PCOS women with full-term singleton delivery were selected, and umbilical cord blood of their newborns was collected. | ||
| Control Group | Healthy pregnant women with full-term singleton delivery were randomly selected, and umbilical cord blood of their newborns was collected. |
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| Measure | Description | Time Frame |
|---|---|---|
| Testosterone | Testosterone is one of the androgens, which can be used to assess androgen levels. | Within one year after neonatal cord blood collection. |
| Androstenedione | Androstenedione is one of the androgens, which can be used to assess androgen levels. | Within one year after neonatal cord blood collection. |
| Dehydroepiandrosterone Sulfate | Dehydroepiandrosterone Sulfate is one of the androgens, which can be used to assess androgen levels. | Within one year after neonatal cord blood collection. |
| Sex Hormone Hinding Globulin | Sex hormone-binding globulin, also known as testosterone-estradiol binding globulin, is a carrier of sex hormones and can reflect the level of sex hormones. | Within one year after neonatal cord blood collection. |
| Free Androgen Index | The free androgen index can reflect the biological activity of androgen. | Within one year after neonatal cord blood collection. |
| Fasting Insulin | Insulin is a hormone secreted by pancreatic beta cells that lowers blood glucose and produces energy metabolism. Its level can assist in the diagnosis of insulin resistance. | Within one year after neonatal cord blood collection. |
| White Blood Cell Count | The white blood cell count can assess the inflammatory status. |
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Inclusion Criteria:
Exclusion Criteria:
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The women selected into the study group were diagnosed with PCOS before pregnancy and were complicated with hyperandrogenism.
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| Name | Affiliation | Role |
|---|---|---|
| Li Li, M.D. | Guangdong Women and Children Hospital | Study Chair |
| Chen Yuan, Master | Guangdong Women and Children Hosptial | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Women and Children Hosptial | Guanzhou | Guangdong | 511400 | China |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Cord Blood
| Within six hours of neonatal cord blood collection. |
| Neutrophil Count | Neutrophil count can be used to assess the inflammatory status. | Within six hours of neonatal cord blood collection. |
| High-sensitivity C-reactive Protein | High-sensitivity C-reactive protein can be used to assess the inflammatory status. | Within six hours of neonatal cord blood collection. |
| Interleukin-6 | Interleukin (IL)-6 can be used to assess the inflammatory status. | Within one year after neonatal cord blood collection. |