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Several studies have demonstrated that direct currents delivered through the skin at the level of the low-thoracic spinal cord can influence spinal cord function. In human volunteers, anodal low-thoracic transcutaneous spinal direct current stimulation (tsDCS) alters spinal processing of nociceptive inputs. Whether cervical tsDCS is able to do the same is less well known. In this double-blinded, sham-controlled and cross-over trial, the investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and low-thoracic tsDCS.
The investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and low-thoracic tsDCS. This study will be a double-blinded, sham-controlled, cross-over trial. Each participant will undergo three experimental sessions (anodal cervical tsDCS and sham thoracic tsDCS vs. sham cervical tsDCS and anodal thoracic tsDCS vs. sham cervical tsDCS and sham thoracic tsDCS), separated by at least one week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal cervical tsDCS | Experimental | Participants will receive:
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| Anodal thoracic tsDCS | Experimental | Participants will receive:
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| Sham tsDCS | Sham Comparator | Participants will receive:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cervical a-tsDCS | Device | Anodal transcutaneous spinal direct current stimulation (a-tsDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in contact-heat evoked potentials amplitude | N2 amplitude | Throughout the entire study, approximately during 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in intensity of perception to contact-heat nociceptive stimuli | Numerical rating scale (0-100) | Throughout the entire study, approximately during 6 months |
| Change in skin temperature | Temperature (°C) |
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Inclusion Criteria:
Healthy young adults
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| André Mouraux, MD, PhD | Contact | +3227645361 | andre.mouraux@uclouvain.be | |
| Arnaud Steyaert, MD | Contact | +3227641821 | arnaud.steyaert@uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| André Mouraux, MD, PhD | Université Catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCLouvain | Recruiting | Brussels | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30321585 | Background | Lenoir C, Jankovski A, Mouraux A. Anodal Transcutaneous Spinal Direct Current Stimulation (tsDCS) Selectively Inhibits the Synaptic Efficacy of Nociceptive Transmission at Spinal Cord Level. Neuroscience. 2018 Nov 21;393:150-163. doi: 10.1016/j.neuroscience.2018.10.007. Epub 2018 Oct 12. |
| Label | URL |
|---|---|
| NOCIONS lab website | View source |
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| ID | Term |
|---|---|
| D059226 | Nociceptive Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| thoracic a-tsDCS | Device | Anodal transcutaneous spinal direct current stimulation (a-tsDCS) |
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| sham tsDCS | Device | Sham transcutaneous spinal direct current stimulation (s-tsDCS) |
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| Throughout the entire study, approximately during 6 months |
| Change in cutaneous blood flow | LDF flow (PU) | Throughout the entire study, approximately during 6 months |