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Several studies have demonstrated that direct currents delivered through the skin at the level of the lumbar spinal cord can influence spinal cord function. In human volunteers, anodal lumbar transcutaneous spinal direct current stimulation (tsDCS) alters spinal processing of nociceptive inputs. Whether cervical tsDCS is able to do the same is less well known.
The investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and lumbar tsDCS. This study will be a double-blinded, sham-controlled, cross-over trial. Each participant will undergo two experimental sessions (anodal cervical tsDCS and sham lumbar tsDCS vs. sham cervical tsDCS and anodal lumbar tsDCS), separated by at least one week.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anodal tsDCS (cervical active, lumbar sham) | Experimental | Participants will receive:
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| Anodal tsDCS (cervical sham, lumbar active) | Active Comparator | Participants will receive:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Starstim (Neuroelectrics) | Device | Anodal transcutaneous spinal direct current stimulation (a-tsDCS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in contact-heat evoked potentials amplitude | N2/P2 amplitude | Change from Baseline, at 15-minutes after the end of stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Change in intensity of perception to contact-heat nociceptive stimuli | Difference in temperature (°C) needed to elicit a pain sensation of similar intensity in the upper and lower limb | Change from Baseline, at 15-minutes after the end of stimulation |
| Change in temporal summation of pain |
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Inclusion Criteria:
- Healthy young adults
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| André Mouraux, MD, PhD | Université Catholique de Louvain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NOCIONS lab | Brussels | 1200 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30321585 | Background | Lenoir C, Jankovski A, Mouraux A. Anodal Transcutaneous Spinal Direct Current Stimulation (tsDCS) Selectively Inhibits the Synaptic Efficacy of Nociceptive Transmission at Spinal Cord Level. Neuroscience. 2018 Nov 21;393:150-163. doi: 10.1016/j.neuroscience.2018.10.007. Epub 2018 Oct 12. |
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| ID | Term |
|---|---|
| D059226 | Nociceptive Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Wind-up ratio (WUR) to mechanical pinprick stimuli |
| Change from Baseline, at 15-minutes after the end of stimulation |
| Change in intensity of perception to mechanical pinprick nociceptive stimuli | Numerical rating scale (0-100) | Change from Baseline, at 15-minutes after the end of stimulation |