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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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The proposed research is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in muscle strength, volume, fatigue resistance, and mobility in older adults after daily consumption of 12g of linoleic acid-rich oil.
Study Objectives
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Linoleic Safflower Oil | Experimental | consumption of 12g of high linoleic safflower oil every day |
|
| High Oleic Safflower Oil | Placebo Comparator | Consumption of 12g of high oleic safflower oil every day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High Linoleic Acid Foods | Other | Two food products containing 6g of high linoleic safflower oil each will be consumed each day for a total of 12g daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes is leg extensor muscle strength | To determine the impact of high linoleic safflower oil on isokinetic leg extensor muscle strength through isokinetic dynamometer | Week 0 and Week 24 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in quadriceps muscle volume | To determine the impact of high linoleic safflower oil on quadriceps muscle volume through MRI | Week 0 and Week 24 |
| Change in maximum leg press strength | To determine the impact of high linoleic safflower oil on maximum leg press strength using leg press machine |
| Measure | Description | Time Frame |
|---|---|---|
| Association of changes in plasma linoleic acid with muscle function | Use multiple linear regressions to determine the association of change in plasma linoleic acid with changes in leg extensor muscle strength | Week 0 and Week 24 |
| Association of changes in plasma linoleic acid with muscle strength |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Martha Belury, PhD RDN | Contact | 614-292-1680 | belury.1@osu.edu | |
| Rachel Cole | Contact | 614-247-8235 | belurylabstudies@osu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Martha Belury, PhD RDN | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ohio State University | Recruiting | Columbus | Ohio | 43210 | United States |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| High Oleic Acid Foods | Other | Two food products containing 6g of high oleic safflower oil each will be consumed each day for a total of 12g daily |
|
| Week 0 and Week 24 |
| Change in leg fatiguability | To determine the impact of high linoleic safflower oil on muscle fatiguability through isokinetic dynamometer | Week 0 and Week 24 |
| Change in muscle mitochondria function | To determine the impact of high linoleic safflower oil on muscle and peripheral blood mononuclear cell mitochondria oxygen consumption rate using the Oroboros instrument | Week 0 and Week 24 |
| Changes in cardiolipin species | To determine the impact of high linoleic safflower oil on muscle and peripheral blood mononuclear cell cardiolipin species measured using electrospray ionization-mass spectrometry coupled to high-performance liquid chromatography. | Week 0 and Week 24 |
| Changes in grip strength | To determine the impact of high linoleic safflower oil on grip strength measured using hand dynamometer. | Week 0 and Week 24 |
| Changes in gait speed | To determine the impact of high linoleic safflower oil on gait speed measured by timing a 400-meter walk. | Week 0 and Week 24 |
| Changes in chair rise time | To determine the impact of high linoleic safflower oil on chair rise time measured by timing rise from a seated position five times. | Week 0 and Week 24 |
| Changes in stair climb power | To determine the impact of high linoleic safflower oil on stair climb time measured by timing the completion of climbing 1 flight of stairs | Week 0 and Week 24 |
| Change in short physical performance battery score | To determine the impact of high linoleic safflower oil on short physical performance battery short score which is calculated by measured by measuring time it takes to walk 4 meters, rise from a chair 5 times and the ability to balance in 3 standing positions for 10 seconds each. Scores range from 0 (predicts for worst physical performance) to 12 (predicts for best physical performance) | Week 0 and Week 24 |
| change in blood fatty acids | To determine the impact of high linoleic safflower oil on changes in blood fatty acids using gas chromatography | Week 0 and Week 24 |
Use multiple linear regressions to determine the association of change in plasma linoleic acid with changes in maximum leg press strength |
| Week 0 and Week 24 |
| Association of changes in plasma linoleic acid with muscle volume | Use multiple linear regressions to determine the association of change in plasma linoleic acid with changes in muscle volume measured by MRI | Week 0 and Week 24 |
| Association of changes 4-LA-cardiolipin with muscle function | Use multiple linear regressions to determine the association of change in 4-LA-cardiolipin with changes in leg extensor muscle strength | Week 0 and Week 24 |
| Association of changes 4-LA-cardiolipin with muscle strength | Use multiple linear regressions to determine the association of change in 4-LA-cardiolipin with changes in maximum leg press strength. | Week 0 and Week 24 |
| Association of changes 4-LA-cardiolipin with muscle volume | Use multiple linear regressions to determine the association of change in 4-LA-cardiolipin with changes in leg muscle volume measured by MRI | Week 0 and Week 24 |
| Association of changes mitochondria function with muscle volume. | Use multiple linear regressions to determine the association of change in mitochondria function with changes in leg muscle volume measured by MRI | Week 0 and Week 24 |
| Association of changes mitochondria function with muscle function | Use multiple linear regressions to determine the association of change in mitochondria function with changes in leg extensor muscle strength. | Week 0 and Week 24 |
| Association of changes mitochondria function with muscle strength. | Use multiple linear regressions to determine the association of change in mitochondria function with changes in maximum leg press strength. | Week 0 and Week 24 |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |