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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA053209 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this study is to assess differences in perceptions of product appeal, harm, and subsequent willingness to try cannabis edibles products with/without packaging imagery.
Cannabis edibles are rapidly leading the legal recreational cannabis market. Cannabis edibles present health harms that are not typical of smoked marijuana, including accidental overconsumption of high levels of Tetrahydrocannabinol (THC) . Product packaging plays an important role in influencing perceptions of a product's appeal and potential harm. This experiment will assign participants to view real cannabis edibles packaging edited with one of four images commonly found on real cannabis edibles products, and ask a series of questions to assess perceptions of product appeal and harm. One group of participants will serve as the control and will see the same cannabis edibles packaging without any imagery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Flavor Imagery | Experimental | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a flavor theme. |
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| Animal Imagery | Experimental | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in an animal theme. |
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| Nature Imagery | Experimental | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a nature theme. |
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| Medical Imagery | Experimental | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a medical theme. |
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| No Imagery (Control) | Experimental | Four edible product packages (gummies, chocolate, mints, cookies) without any added packaging imagery. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Packaging imagery | Behavioral | Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| Measure | Description | Time Frame |
|---|---|---|
| Product Appeal Scoring | One item to assess the appeal of the product. Results will be reported as mean for all products within condition. Question: How appealing is this product to you? Response options: (0) Not at all appealing to (10) Very appealing | After exposure to product packaging - up to 1 min |
| Package Appeal Scoring | One item to assess appeal of the packaging of the product. Results will be reported as mean for all products within condition. Question: How appealing is this packaging to you? Response options: (0) Not at all appealing to (10) Very appealing | After exposure to product packaging - up to 1 min |
| Product Harm Perceptions (Absolute) Scoring | After exposure to product packaging; 1 min One item to assess participants' opinions of safety of the product. Results will be reported as the number of each type of response. Question: How safe do you think it would be to eat the edible in this package? Response options: (1) Completely unsafe, (2) Somewhat unsafe, (3) Somewhat safe, (4) Completely safe | After exposure to product packaging - up to 1 min |
| Package Harm Perceptions (Absolute) Scoring | One item to assess participants' opinions of product safety based on the packaging. Results will be reported as the number of each type of response. Question: How much does this packaging make you think this edible is safe to consume? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | After exposure to product packaging - up to 1 min |
| Willingness to Try Free Sample Scoring | One question will assess the participant's willingness to try the product shown. Results will be reported as the number of each type of response. Question: How interested would you be in a free sample of this product? Response options: (1) Not at all; (2) Slightly; (3) Somewhat; (4) Moderately; (5) Very |
| Measure | Description | Time Frame |
|---|---|---|
| Appeal to Children Scoring | One item to assess the participants' assessment of the product packaging's potential appeal to children. Results will be reported as mean for all products within condition. Question: How appealing do you think this packaging would be to children? Response options: (0) Not at all appealing to (10) Very appealing | After exposure to product packaging - up to 1 min |
| Measure | Description | Time Frame |
|---|---|---|
| Perception of Quality Scoring | One item to assess the participants' perceptions of the quality of the product. Results will be reported as the number of each type of response. Question: To what extent do you agree or disagree that this looks like a good quality product? Response options: (1) Strongly disagree to (5) Strongly agree | After exposure to product packaging - up to 1 min |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Beth Reboussin, PhD | Wake Forest University Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42176349 | Derived | Reboussin BA, Lazard AJ, Wagoner KG, Sutfin EL, Romero-Sandoval EA, Egan KL, Suerken CK, Zizzi AR, Horton OE, Lake S, Varma T, Cork K, Cornacchione Ross J. The Impact of Product Packaging on Perceptions of Cannabis Edibles: Results from Two Randomized Experiments. Subst Use Misuse. 2026 May 23:1-11. doi: 10.1080/10826084.2026.2670605. Online ahead of print. |
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Approximately 50% of the participants reported using waterpipe within the past year; the remaining 50% of the sample consisted of not-past-year users and never users.
Participants were recruited from online survey panels.
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| ID | Title | Description |
|---|---|---|
| FG000 | No Imagery (Control) | Four edible product packages (gummies, chocolate, mints, cookies) without any added packaging imagery. No Imagery (Control): Participants in the control condition will see the same four product packages, but without any added imagery. |
| FG001 | Flavor Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a flavor theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| FG002 | Nature Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a nature theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| FG003 | Medical Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a medical theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| FG004 | Animal Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in an animal theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | No Imagery (Control) | Four edible product packages (gummies, chocolate, mints, cookies) without any added packaging imagery. No Imagery (Control): Participants in the control condition will see the same four product packages, but without any added imagery. |
| BG001 | Flavor Imagery |
| Units | Counts |
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| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Product Appeal Scoring | One item to assess the appeal of the product. Results will be reported as mean for all products within condition. Question: How appealing is this product to you? Response options: (0) Not at all appealing to (10) Very appealing | Posted | Mean | Standard Error | Score on a scale | After exposure to product packaging - up to 1 min |
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From the time of consent up to completion of the survey (approximately 1 hour).
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | No Imagery (Control) | Four edible product packages (gummies, chocolate, mints, cookies) without any added packaging imagery. No Imagery (Control): Participants in the control condition will see the same four product packages, but without any added imagery. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Beth Reboussin, PhD | Wake Forest University Health Sciences | 336-713-5213 | brebouss@wakehealth.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 19, 2025 | May 2, 2025 | Prot_SAP_001.pdf |
| ICF | No | No | Yes | Informed Consent Form | Apr 2, 2024 | Aug 29, 2024 | ICF_000.pdf |
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Participants will complete a 15-minute online survey, where they will be randomized to one of five conditions: four intervention conditions with a different image on the package and one without any imagery.
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| No Imagery (Control) | Behavioral | Participants in the control condition will see the same four product packages, but without any added imagery. |
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| After exposure to product packaging - up to 1 min |
| Willingness to Try Product Scoring | One item to assess the participants' willingness to try the product based on the packaging. Results will be reported as the number of each type of response. Question: How much does seeing this packaging make you want to try this edible? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | After exposure to product packaging - up to 1 min |
| Harm Perceptions (Relative) Scoring | One question assessing participants' opinions of safety of the product compared to other, similar, products. Results will be reported as the number of each type of response. Question: Compared to other edible products on the market, how safe do you think the edible in this package is? Response options: (1) Much less safe; (2) Somewhat less safe; (3) As safe; (4) Somewhat safer; (5) Much safer | After exposure to product packaging - up to 1 min |
| Perception of Good Taste Scoring | One item to assess the participants' perceptions of the taste of the product. Results will be reported as the number of each type of response. Question: To what extent do you agree or disagree that this edible might taste good? Response options: (1) Strongly disagree to (5) Strongly agree | After exposure to product packaging - up to 1 min |
| Perception of Healthfulness of Product Scoring | One item to asses the participants' perceptions of the healthfulness of the product based on the packaging. Results will be reported as the number of each type of response. Question: How much does this packaging make you think this edible is healthy? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | After exposure to product packaging - up to 1 min |
Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a flavor theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| BG002 | Nature Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a nature theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| BG003 | Medical Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a medical theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| BG004 | Animal Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in an animal theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| BG005 | Total | Total of all reporting groups |
| Years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| OG002 | Nature Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a nature theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| OG003 | Medical Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a medical theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
| OG004 | Animal Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in an animal theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. |
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| Primary | Package Appeal Scoring | One item to assess appeal of the packaging of the product. Results will be reported as mean for all products within condition. Question: How appealing is this packaging to you? Response options: (0) Not at all appealing to (10) Very appealing | Posted | Mean | Standard Error | Score on a scale | After exposure to product packaging - up to 1 min |
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| Primary | Product Harm Perceptions (Absolute) Scoring | After exposure to product packaging; 1 min One item to assess participants' opinions of safety of the product. Results will be reported as the number of each type of response. Question: How safe do you think it would be to eat the edible in this package? Response options: (1) Completely unsafe, (2) Somewhat unsafe, (3) Somewhat safe, (4) Completely safe | Posted | Count of Units | Number of responses on scale 1-4 | After exposure to product packaging - up to 1 min | Number of responses on scale 1-4 | Number of responses on scale 1-4 |
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| Primary | Package Harm Perceptions (Absolute) Scoring | One item to assess participants' opinions of product safety based on the packaging. Results will be reported as the number of each type of response. Question: How much does this packaging make you think this edible is safe to consume? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | Posted | Count of Units | Number of responses on scale 1-4 | After exposure to product packaging - up to 1 min | Number of responses on scale 1-4 | Number of responses on scale 1-4 |
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| Primary | Willingness to Try Free Sample Scoring | One question will assess the participant's willingness to try the product shown. Results will be reported as the number of each type of response. Question: How interested would you be in a free sample of this product? Response options: (1) Not at all; (2) Slightly; (3) Somewhat; (4) Moderately; (5) Very | Posted | Count of Units | Number of responses on scale 1-5 | After exposure to product packaging - up to 1 min | Number of responses on scale 1-5 | Number of responses on scale 1-5 |
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| Primary | Willingness to Try Product Scoring | One item to assess the participants' willingness to try the product based on the packaging. Results will be reported as the number of each type of response. Question: How much does seeing this packaging make you want to try this edible? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | Posted | Count of Units | Number of responses on scale 1-4 | After exposure to product packaging - up to 1 min | Number of responses on scale 1-4 | Number of responses on scale 1-4 |
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| Secondary | Appeal to Children Scoring | One item to assess the participants' assessment of the product packaging's potential appeal to children. Results will be reported as mean for all products within condition. Question: How appealing do you think this packaging would be to children? Response options: (0) Not at all appealing to (10) Very appealing | Posted | Mean | Standard Error | Score on a scale | After exposure to product packaging - up to 1 min |
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| Secondary | Harm Perceptions (Relative) Scoring | One question assessing participants' opinions of safety of the product compared to other, similar, products. Results will be reported as the number of each type of response. Question: Compared to other edible products on the market, how safe do you think the edible in this package is? Response options: (1) Much less safe; (2) Somewhat less safe; (3) As safe; (4) Somewhat safer; (5) Much safer | Posted | Count of Units | Number of responses on scale 1-5 | After exposure to product packaging - up to 1 min | Number of responses on scale 1-5 | Number of responses on scale 1-5 |
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| Other Pre-specified | Perception of Quality Scoring | One item to assess the participants' perceptions of the quality of the product. Results will be reported as the number of each type of response. Question: To what extent do you agree or disagree that this looks like a good quality product? Response options: (1) Strongly disagree to (5) Strongly agree | Not Posted | After exposure to product packaging - up to 1 min | Participants |
| Other Pre-specified | Perception of Good Taste Scoring | One item to assess the participants' perceptions of the taste of the product. Results will be reported as the number of each type of response. Question: To what extent do you agree or disagree that this edible might taste good? Response options: (1) Strongly disagree to (5) Strongly agree | Not Posted | After exposure to product packaging - up to 1 min | Participants |
| Other Pre-specified | Perception of Healthfulness of Product Scoring | One item to asses the participants' perceptions of the healthfulness of the product based on the packaging. Results will be reported as the number of each type of response. Question: How much does this packaging make you think this edible is healthy? Response options: (1) Not at all; (2) A little; (3) Somewhat; (4) A lot | Not Posted | After exposure to product packaging - up to 1 min | Participants |
| 0 |
| 254 |
| 0 |
| 254 |
| 0 |
| 254 |
| EG001 | Flavor Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a flavor theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. | 0 | 244 | 0 | 244 | 0 | 244 |
| EG002 | Nature Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a nature theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. | 0 | 245 | 0 | 245 | 0 | 245 |
| EG003 | Medical Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in a medical theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. | 0 | 252 | 0 | 252 | 0 | 252 |
| EG004 | Animal Imagery | Four edible product packages (gummies, chocolate, mints, cookies) with package imagery in an animal theme. Packaging imagery: Participants in the four intervention conditions will be shown four cannabis edibles packages that have been altered to contain one of the imagery themes. All participants will see the same four products, and each condition will see the products with the same imagery theme. | 0 | 265 | 0 | 265 | 0 | 265 |
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| Number of responses on scale 1-4 |
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| (2) Somewhat unsafe |
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| (3) Somewhat safe |
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| (4) Completely safe |
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| Number of responses on scale 1-4 |
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| (2) A little |
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| (3) Somewhat |
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| (4) A lot |
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| Number of responses on scale 1-5 |
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| (2) Slightly |
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| (3) Somewhat |
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| (4) Moderately |
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| (5) Very |
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| Number of responses on scale 1-4 |
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| (2) A little |
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| (3) Somewhat |
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| (4) A lot |
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| Number of responses on scale 1-5 |
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| (2) Somewhat less safe |
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| (3) As safe |
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| (4) Somewhat safer |
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| (5) Much safer |
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